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Effects of Fluoxeti...
Effects of Fluoxetine on Outcomes at 12 Months After Acute Stroke Results From EFFECTS, a Randomized Controlled Trial
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- Lundström, Erik, 1964- (författare)
- Uppsala universitet,Landtblom: Neurovetenskap,Akademiska sjukhuset, Ing 85 2 tr, Uppsala SE-751 85, Sweden
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- Isaksson, Eva (författare)
- Karolinska Institutet,Uppsala universitet,Karolinska Institute,Department of Clinical Neuroscience, Neurology (E.I.), Karolinska Institutet, Stockholm. Department of Neurology, Danderyd Hospital, Stockholm, Sweden (E.I.).,Institutionen för neurovetenskap
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- Greilert Norin, Nina (författare)
- Karolinska Inst, Dept Clin Neurosci Neurol, Stockholm, Sweden.,Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden,Department of Clinical Sciences, Danderyd Hospital (N.G.N.), Karolinska Institutet, Stockholm
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- Näsman, Per, Docent, 1954- (författare)
- KTH Royal Institute of Technology,KTH,Fastighetsekonomi och finans,Centre for Safety Research, KTH Royal Institute of Technology, Stockholm, Sweden (P.N.)
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- Wester, Per, 1959- (författare)
- Karolinska Institutet,Umeå University,Karolinska Institute,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences (P.W.), Karolinska Institutet, Stockholm. Department of Public Health & Clinical Medicine, Umeå University, Sweden (P.W.),Karolinska Inst, Dept Clin Sci, Stockholm, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.
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- Martensson, Björn (författare)
- Karolinska Institutet,Karolinska Institute,Department of Clinical Neurosciences (B.M.), Karolinska Institutet, Stockholm
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- Norrving, Bo (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Department of Clinical Sciences, Neurology, Lund University, Sweden (B.N.)
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- Wallén, Håkan (författare)
- Karolinska Institutet,Karolinska Institute,Department of Clinical Sciences (H.W.), Karolinska Institutet, Stockholm
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- Borg, Jörgen (författare)
- Karolinska Institutet,Karolinska Institute,Department of Neuroscience, NeurologyDepartment of Clinical Sciences (J.B.) Department of Clinical Sciences (J.B.), Karolinska Institutet, Stockholm
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- Hankey, Graeme J. (författare)
- Univ Western Australia, Med Sch, Fac Hlth & Med Sci, Perth, WA, Australia.;Sir Charles Gairdner Hosp, Dept Neurol, Perth, WA, Australia.,Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia; Department of Neurology, Sir Charles Gairdner Hospital, WA, Perth, Australia,University of Western Australia, Crawley
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- Hackett, Maree L. (författare)
- Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Univ Cent Lancashire, Preston, Lancs, England.,George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia; University of Central Lancashire, United Kingdom
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- Mead, Gillian E. (författare)
- Univ Edinburgh, Royal Infirm, Edinburgh, Midlothian, Scotland.,University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom
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- Dennis, Martin S. (författare)
- Univ Edinburgh, Royal Infirm, Edinburgh, Midlothian, Scotland.,University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom
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- Stibrant Sunnerhagen, Katharina, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2021
- 2021
- Engelska.
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Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 52:10, s. 3082-3087
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: The EFFECTS (Efficacy of Fluoxetine-a Randomised Controlled Trial in Stroke) recently reported that 20 mg fluoxetine once daily for 6 months after acute stroke did not improve functional outcome but reduced depression and increased fractures and hyponatremia at 6 months. The purpose of this predefined secondary analysis was to identify if any effects of fluoxetine were maintained or delayed over 12 months. METHODS: EFFECTS was an investigator-led, randomized, placebo-controlled, double-blind, parallel group trial in Sweden that enrolled adult patients with stroke. Patients were randomized to 20 mg oral fluoxetine or matching placebo for 6 months and followed for another 6 months. The primary outcome was functional outcome (modified Rankin Scale), at 6 months. Predefined secondary outcomes for these analyses included the modified Rankin Scale, health status, quality of life, fatigue, mood, and depression at 12 months. RESULTS: One thousand five hundred patients were recruited from 35 centers in Sweden between 2014 and 2019; 750 were allocated fluoxetine and 750 placebo. At 12 months, modified Rankin Scale data were available in 715 (95%) patients allocated fluoxetine and 712 (95%) placebo. The distribution of modified Rankin Scale categories was similar in the 2 groups (adjusted common odds ratio, 0.92 [95% CI, 0.76-1.10]). Patients allocated fluoxetine scored worse on memory with a median value of 89 (interquartile range, 75-100) versus 93 (interquartile range, 82-100); P=0.0021 and communication 93 (interquartile range, 82-100) versus 96 (interquartile range, 86-100); P=0.024 domains of the Stroke Impact Scale compared with placebo. There were no other differences in secondary outcomes. CONCLUSIONS: Fluoxetine after acute stroke had no effect on functional outcome at 12 months. Patients allocated fluoxetine scored worse on memory and communication on the Stroke Impact Scale compared with placebo, but this is likely to be due to chance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- antidepressive agents
- disability studies
- fluoxetine
- functional status
- randomized controlled trial
- serotonin uptake inhibitors
- stroke
- antidepressive agents
- disability studies
- fluoxetine
- functional status
- randomized controlled trial
- serotonin uptake inhibitors
- stroke
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Stroke
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- Av författaren/redakt...
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Lundström, Erik, ...
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Isaksson, Eva
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Greilert Norin, ...
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Näsman, Per, Doc ...
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Wester, Per, 195 ...
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Martensson, Björ ...
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Norrving, Bo
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Wallén, Håkan
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Borg, Jörgen
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Hankey, Graeme J ...
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Hackett, Maree L ...
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Mead, Gillian E.
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Dennis, Martin S ...
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Stibrant Sunnerh ...
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Stroke
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Kungliga Tekniska Högskolan
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Umeå universitet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet
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Göteborgs universitet