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A TNF-like Trimeric...
A TNF-like Trimeric Lectin Domain from Burkholdeda cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens
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- Sulak, Ondrej (författare)
- CERMAV CNRS, F-38041 Grenoble 9, France.;Masaryk Univ, Fac Sci, Natl Ctr Biomol Res, CS-61137 Brno, Czech Republic.
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- Cioci, Gianluca (författare)
- European Synchrotron Radiat Facil, F-38043 Grenoble, France.
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- Delia, Monia (författare)
- Masaryk Univ, Fac Sci, Natl Ctr Biomol Res, CS-61137 Brno, Czech Republic.
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- Lahmann, Martina (författare)
- Univ Bangor, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
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- Varrot, Annabelle (författare)
- CERMAV CNRS, F-38041 Grenoble 9, France.
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- Imberty, Anne (författare)
- CERMAV CNRS, F-38041 Grenoble 9, France.
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- Wimmerova, Michaela (författare)
- Masaryk Univ, Fac Sci, Natl Ctr Biomol Res, CS-61137 Brno, Czech Republic.;Masaryk Univ, Dept Biochem, Fac Sci, CS-61137 Brno, Czech Republic.
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CERMAV CNRS, F-38041 Grenoble 9, France;Masaryk Univ, Fac Sci, Natl Ctr Biomol Res, CS-61137 Brno, Czech Republic. European Synchrotron Radiat Facil, F-38043 Grenoble, France. (creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Structure. - : Elsevier BV. - 0969-2126 .- 1878-4186. ; 18:1, s. 59-72
- Relaterad länk:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C. This lectin exhibits two domains: a C-terminal domain with high sequence similarity to the recently described calcium-dependent mannose-binding lectin BC2L-A, and an N-terminal domain of 156 amino acids without similarity to any known protein. The recombinant N-terminal BC2L-C domain is a new lectin with specificity for fucosylated human histo-blood group epitopes H-type 1, Lewis b, and Lewis Y, as determined by glycan array and isothermal titration calorimetry. Methylselenofucoside was used as ligand to solve the crystal structure of the N-terminal BC2L-C domain. Additional molecular modeling studies rationalized the preference for Lewis epitopes. The structure reveals a trimeric jellyroll arrangement with striking similarity to TNF-like proteins, and to BcIA, the spore protein from Bacillus anthracis which may play an important role in bioadhesion of anthrax spores in human lungs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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