Lectin-Functionalized Polyethylene Glycol for Relief of Mucosal Dryness

QC 20220615
The importance of lubrication between oral surfaces provided by the salivary film is most acutely apparent when it is disrupted, a prevalent consequence of salivary gland hypofunction experienced with aging, a symptom of certain diseases, or a side effect of some medical interventions. Sufferers report difficulty with speech and oral food processing and collectively is detrimental to quality of life. Polyethylene glycol (PEG) is widely employed as a successful biocompatible boundary lubricant in engineering and biomedical applications. It is hypothesized that the immobilization of PEG to biological materials such as oral epithelial cells and tissue can mimic the salivary film and provide durable relief from the symptoms of mucosal dryness. To do so, PEG is functionalized with a sugar binding lectin (wheat germ agglutinin) to enhance epithelial adhesion through lectin-sugar interactions. Retention and lubricity are characterized on an ex vivo oral tissue tribology rig. WGA-PEG coats and retains on mucin films, oral epithelial cells, and porcine tongue tissue, and offers sustained reduction in coefficient of friction (COF). WGA-PEG could be developed into a useful topical treatment for reducing oral friction and the perception of dry mouth.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Biocompatibility
Cells
Food processing
Friction
Medical applications
Polyethylenes
Proteins
Tissue
Tribology
Boundary lubricants
Dry mouth
Epithelial cells
Functionalised-polyethylene glycol
Lubrication /
Medical intervention
Mucosal dryness
Quality of life
Salivary glands
Side effect
Polyethylene glycols
macrogol
mucin
wheat germ agglutinin
lectin
aging
animal tissue
Article
cell adhesion
controlled study
epithelium cell
ex vivo study
human
human cell
lubrication
mouth epithelium
mouth mucosa
nonhuman
pig
protein carbohydrate interaction
saliva
salivary gland disease
speech disorder
animal
metabolism
xerostomia
Animals
Lectins
Swine

Sharma, P. K.Department of Biomedical Engineering, University of Groningen and University Medical Centre Groningen, Groningen, 9713 AV, Netherlands (författare)
Kaper, H. J.Department of Biomedical Engineering, University of Groningen and University Medical Centre Groningen, Groningen, 9713 AV, Netherlands (författare)
Bostanci, N.Karolinska Institutet (författare)
Crouzier, ThomasKTH,Glykovetenskap,AIMES – Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet ; Department of Neuroscience, Karolinska Institutet, Stockholm, 171 77, Sweden(Swepub:kth)u1hi6ps2 (författare)
KTHGlykovetenskap (creator_code:org_t)

Av författaren/redakt...: Blakeley, Matthe ...; Sharma, P. K.; Kaper, H. J.; Bostanci, N.; Crouzier, Thomas

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