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Sökning: onr:"swepub:oai:DiVA.org:kth-313560" > Validation of Rapid...

  • Ouellette, R.Karolinska Institutet (författare)

Validation of Rapid Magnetic Resonance Myelin Imaging in Multiple Sclerosis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-03-02
  • Wiley,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-313560
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313560URI
  • https://doi.org/10.1002/ana.25705DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165837URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143818078URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20220613
  • Objective: Magnetic resonance imaging (MRI) is essential for multiple sclerosis diagnostics but is conventionally not specific to demyelination. Myelin imaging is often hampered by long scanning times, complex postprocessing, or lack of clinical approval. This study aimed to assess the specificity, robustness, and clinical value of Rapid Estimation of Myelin for Diagnostic Imaging, a new myelin imaging technique based on time-efficient simultaneous T1/T2 relaxometry and proton density mapping in multiple sclerosis. Methods: Rapid myelin imaging was applied using 3T MRI ex vivo in 3 multiple sclerosis brain samples and in vivo in a prospective cohort of 71 multiple sclerosis patients and 21 age/sex-matched healthy controls, with scan–rescan repeatability in a subcohort. Disability in patients was assessed by the Expanded Disability Status Scale and the Symbol Digit Modalities Test at baseline and 2-year follow-up. Results: Rapid myelin imaging correlated with myelin-related stains (proteolipid protein immunostaining and Luxol fast blue) and demonstrated good precision. Multiple sclerosis patients had, relative to controls, lower normalized whole-brain and normal-appearing white matter myelin fractions, which correlated with baseline cognitive and physical disability. Longitudinally, these myelin fractions correlated with follow-up physical disability, even with correction for baseline disability. Interpretation: Rapid Estimation of Myelin for Diagnostic Imaging provides robust myelin quantification that detects diffuse demyelination in normal-appearing tissue in multiple sclerosis, which is associated with both cognitive and clinical disability. Because the technique is fast, with automatic postprocessing and US Food and Drug Administration/CE clinical approval, it can be a clinically feasible biomarker that may be suitable to monitor myelin dynamics and evaluate treatments aiming at remyelination.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Mangeat, G.A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada (författare)
  • Polyak, I.Invicro, Boston, MA, United States (författare)
  • Warntjes, Marcel, Jan Bertus,1973-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,SyntheticMR, Linköping, Sweden(Swepub:liu)marwa64 (författare)
  • Forslin, Y.Karolinska Institutet (författare)
  • Bergendal, Å.Karolinska Institutet (författare)
  • Platten, MichaelKarolinska Institutet,KTH,Medicinteknik och hälsosystem,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; School of Engineering Sciences in Chemistry, Biology, and Health, Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u19rh8fr (författare)
  • Uppman, M.Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Treaba, C. A.A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States (författare)
  • Cohen-Adad, J.NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada (författare)
  • Piehl, F.Karolinska Institutet (författare)
  • Kristoffersen Wiberg, M.Karolinska Institutet (författare)
  • Fredrikson, S.Karolinska Institutet (författare)
  • Mainero, C.A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States (författare)
  • Granberg, T.Karolinska Institutet (författare)
  • Karolinska InstitutetA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of Neurology: Wiley87:5, s. 710-7240364-51341531-8249

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