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Diagnostic performa...
Diagnostic performance of CT-derived resting distal to aortic pressure ratio (resting Pd/Pa) vs. CT-derived fractional flow reserve (CT-FFR) in coronary lesion severity assessment
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- Li, Quan (författare)
- Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.
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- Zhang, Yang (författare)
- Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.
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- Wang, Chunliang, 1980- (författare)
- KTH,Medicinsk avbildning,Shenzhen Escope Tech Inc, Shenzhen, Peoples R China.
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- Dong, Shiming (författare)
- Second Mil Med Univ, Changzheng Hosp, Dept Cardiol, Shanghai, Peoples R China.
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- Mao, Yijin (författare)
- Shenzhen Escope Tech Inc, Shenzhen, Peoples R China.
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- Tang, Yida (författare)
- Peking Univ Third Hosp, Dept Cardiovasc Med, Beijing 100191, Peoples R China.
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- Zeng, Yong (författare)
- Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.
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Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China Medicinsk avbildning (creator_code:org_t)
- 2021-09
- 2021
- Engelska.
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Ingår i: Annals of Translational Medicine. - : AME Publishing Company. - 2305-5839 .- 2305-5847. ; 9:17
- Relaterad länk:
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https://atm.amegroup...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: Computed tomography-derived fractional flow reserve (CT-FFR) has emerged as a promising non-invasive substitute for fractional flow reserve (FFR) measurement. Normally, CT-FFR providing functional significance of coronary artery disease (CAD) by using a simplified total coronary resistance index (TCRI) model. Yet the error or discrepancy caused by this simplified model remains unclear. Methods: A total of 20 consecutive patients with suspected CAD who underwent CTA and invasive FFR measurement were retrospectively analyzed. CT-FFR and CT-(Pd/Pa)rest values derived from the coronary CTA images. The diagnostic performance of CT-FFR and CT-(Pd/Pa)rest were evaluated on a per-vessel level using C statistics with invasive FFR<0.80 as the reference standard. Results: Of the 25 vessels eventually analyzed, the prevalence of functionally significant CAD were 64%. The Youden index of the ROC curve indicated that the best cutoff value of invasive resting Pd/Pa was 0.945 for identifying functionally significant lesions. Sensitivity, specificity, negative predictive value, positive predictive value and accuracy were 85%, 91%, 92%, 83% and 88% for CT-(Pd/Pa)rest and 85%, 58% 69%, 78% and 72% for CT-FFR. Area under the receiver-operating characteristic curve (AUC) to detect functionally significant stenoses of CT-(Pd/Pa)rest and CT-FFR were 0.87 and 0.90. Conclusions: In this study, the results suggest CT-derived resting Pd/Pa has a potential advantage over CT-FFR in triaging patients for revascularization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Fractional flow reserve (FFR)
- computational fluid dynamics
- coronary CT angiography
- pressure ratio
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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