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SARS-CoV-2 (COVID-1...
SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis : Monozygotic twins pair case observation
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- Arruda, L. C. M. (författare)
- Karolinska Institutet
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- Gaballa, A. (författare)
- Karolinska Institutet
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Da Silva Rodrigues, R. (författare)
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Makower, B. (författare)
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- Uhlin, Michael (författare)
- Karolinska Institutet,KTH,Biofysik,Science for Life Laboratory, SciLifeLab,Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
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(creator_code:org_t)
- 2022-03-02
- 2022
- Engelska.
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Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 95:5
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Rheumatoid arthritis (RA) patients present higher risk of SARS-CoV-2 infection (COVID-19), and proper management of the disease in this population requires a better understanding of how the immune system controls the virus. We analyzed the T cell and B cell phenotypes, and their repertoire in a pair of monozygotic twins with RA mismatched for COVID-19 infection. Twin- was not infected, while Twin+ was infected and effectively controlled the infection. We found no significant changes on the αβ T cell composition, while γδ T cells and B cells presented considerable expansion of memory population in Twin+ and robust T/B cell responses to several SARS-CoV-2 peptides. T cell receptor β/γ-chain and immunoglobulin heavy chain next-generation sequencing depicted a remarkable higher diversity in Twin+ compared with Twin-, despite no significant changes being found in variable/joining family usage. Repertoire overlap analyses showed that, although being identical twins, very few clones were shared between them, indicating that COVID-19 may lead to deep changes on the immune cell repertoire in RA patients. Altogether, our results indicate that RA patients may develop robust and persistent COVID-19-specific T/B cell responses; γδ T cells and B cells may play a key role in the management of COVID-19 in RA, and the infection may lead to a profound reshaping of immune cell receptor specificities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- COVID-19
- immunoglobulin heavy chain
- next-generation sequencing
- SARS-CoV-2
- T cell receptor
- adalimumab
- coronavirus protein
- cyclic citrullinated peptide antibody
- methotrexate
- T lymphocyte receptor beta chain
- T lymphocyte receptor gamma chain
- lymphocyte antigen receptor
- adult
- Article
- B lymphocyte
- case report
- cell expansion
- cellular immunity
- clinical article
- clone
- controlled study
- convalescence
- coronavirus disease 2019
- gamma delta T lymphocyte
- high throughput sequencing
- human
- human cell
- male
- middle aged
- monozygotic twins
- nonhuman
- phenotype
- rheumatoid arthritis
- Severe acute respiratory syndrome coronavirus 2
- T lymphocyte
- genetics
- twins
- Arthritis
- Rheumatoid
- Diseases in Twins
- Humans
- Receptors
- Antigen
- T-Cell
- alpha-beta
- Receptors
- Antigen
- T-Cell
- gamma-delta
- T-Lymphocytes
- Twins
- Monozygotic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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