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Cholinergic regulat...
Cholinergic regulation of vascular endothelial function by human ChAT + T cells
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- Tarnawski, Laura (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Shavva, Vladimir S. (författare)
- Karolinska Institutet
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- Kort, Eric J. (författare)
- DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503,Van Andel Res Inst, MI 49503 USA; Fredrik Meijer Heart & Vasc Inst, MI 49503 USA
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- Zhuge, Zhengbing (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden,Karolinska Inst, Sweden
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- Nilsson, Ingrid (författare)
- Karolinska Institutet
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- Gallina, Alessandro L. (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Martínez-Enguita, David (författare)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Heller Sahlgren, Benjamin (författare)
- Karolinska Institutet
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- Weiland, Matthew (författare)
- DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503,Van Andel Res Inst, MI 49503 USA; Fredrik Meijer Heart & Vasc Inst, MI 49503 USA
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- Caravaca, April S. (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Schmidt, Staffan (författare)
- Karolinska Institutet
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- Chen, Ping (författare)
- Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Stockholm, Sweden,Karolinska Inst, Sweden
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- Abbas, Katarina (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Wang, Fu-Hua (författare)
- Pronexus Analytical AB, Bromma, 167 33 Stockholm, Sweden,Pronexus Analyt AB, Sweden
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- Ahmed, Osman (författare)
- Karolinska Institutet
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- Eberhardson, Michael (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Karolinska Univ Hosp, Sweden
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- Färnert, Anna (författare)
- Karolinska Institutet
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- Weitzberg, Eddie (författare)
- Karolinska Institutet
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- Gustafsson, Mika (författare)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Kehr, Jan (författare)
- Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden;Pronexus Analytical AB, Bromma, 167 33 Stockholm, Sweden,Karolinska Inst, Sweden; Pronexus Analyt AB, Sweden
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- Malin, Stephen G. (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Hult, Henrik, 1975- (författare)
- KTH,Matematisk statistik,KTH Royal Inst Technol, Sweden
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- Carlström, Mattias (författare)
- Karolinska Institutet
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- Jovinge, Stefan (författare)
- DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503;Cardiovascular Institute, Stanford University, Palo Alto, CA 94305,Van Andel Res Inst, MI 49503 USA; Fredrik Meijer Heart & Vasc Inst, MI 49503 USA; Stanford Univ, CA 94305 USA
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- Olofsson, Peder S. (författare)
- Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden;Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY 11030
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(creator_code:org_t)
- 2023-03-29
- 2023
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 120:14
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Endothelial dysfunction and impaired vasodilation are linked with adverse cardiovascular events. T lymphocytes expressing choline acetyltransferase (ChAT), the enzyme catalyzing biosynthesis of the vasorelaxant acetylcholine (ACh), regulate vasodilation and are integral to the cholinergic antiinflammatory pathway in an inflammatory reflex in mice. Here, we found that human T cell ChAT mRNA expression was induced by T cell activation involving the PI3K signaling cascade. Mechanistically, we identified that ChAT mRNA expression was induced following the attenuation of RE-1 Silencing Transcription factor REST-mediated methylation of the ChAT promoter, and that ChAT mRNA expression levels were up-regulated by GATA3 in human T cells. In functional experiments, T cell-derived ACh increased endothelial nitric oxide-synthase activity, promoted vasorelaxation, and reduced vascular endothelial activation and promoted barrier integrity by a cholinergic mechanism. Further, we observed that survival in a cohort of patients with severe circulatory failure correlated with their relative frequency of ChAT+CD4+ T cells in blood. These findings on ChAT+ human T cells provide a mechanism for cholinergic immune regulation of vascular endothelial function in human inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- acetylcholine
- circulation
- lymphocytes
- vascular biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tarnawski, Laura
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Shavva, Vladimir ...
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Kort, Eric J.
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Zhuge, Zhengbing
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Nilsson, Ingrid
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Gallina, Alessan ...
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visa fler...
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Martínez-Enguita ...
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Heller Sahlgren, ...
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Weiland, Matthew
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Caravaca, April ...
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Schmidt, Staffan
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Chen, Ping
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Abbas, Katarina
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Wang, Fu-Hua
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Ahmed, Osman
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Eberhardson, Mic ...
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Färnert, Anna
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Weitzberg, Eddie
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Gustafsson, Mika
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Kehr, Jan
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Malin, Stephen G ...
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Hult, Henrik, 19 ...
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Carlström, Matti ...
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Jovinge, Stefan
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Olofsson, Peder ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Cell och molekyl ...
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- Av lärosätet
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Kungliga Tekniska Högskolan
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Linköpings universitet
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Karolinska Institutet