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Ultrasome :
Ultrasome : efficient aberration caller for copy number studies of ultra-high resolution
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- Nilsson, Björn (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Johansson, Mikael (författare)
- KTH,Reglerteknik
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Al-Shahrour, Fatima (författare)
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Carpenter, Anne E. (författare)
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Ebert, Benjamin L. (författare)
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(creator_code:org_t)
- 2009-02-19
- 2009
- Engelska.
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Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811 .- 1460-2059. ; 25:8, s. 1078-1079
- Relaterad länk:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- DNA
- accuracy
- article
- chromosome aberration
- computer program
- controlled study
- DNA microarray
- gene number
- human
- human cell
- information processing
- intermethod comparison
- mathematical analysis
- priority journal
- receiver operating characteristic
- Ultrasome
- Algorithms
- Chromosome Aberrations
- Computational Biology
- Gene Dosage
- Gene Expression Profiling
- Oligonucleotide Array Sequence Analysis
- Polymorphism
- Single Nucleotide
- Bioinformatics
- Bioinformatik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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