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A smartphone powere...
A smartphone powered centrifugal microfluidic platform for point-of-care diagnostics in resource limited settings
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- Lapins, Noa (författare)
- KTH,Nanobioteknologi
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- Akhtar, Ahmad Saleem (författare)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Banerjee, Indradumna (författare)
- KTH,Nanobioteknologi
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visa fler...
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- Kazemzadeh, Amin (författare)
- KTH,Nanobioteknologi
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- Pinto, Ines Fernandes (författare)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Russom, Aman, Prof. 1976- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The broad availability of smartphones has provided new opportunities to develop less expensive, portable and integrated point-of-care (POC) platforms. To date, many point-of-care devices have been developed that employ the computing power and the optical sensing capabilities available in smartphones. Here, a platform that consists of three main components is introduced: a portable housing, a centrifugal microfluidic disc and a mobile phone. The mobile phone supplies the electrical power and serves as an analysing system that captures and processes the test images. The housing made from cardboard serves as a platform to conduct tests and ensures the portability and rigidity of the platform while being extremely low-cost. The electrical energy stored in mobile phones was demonstrated to be adequate for spinning a centrifugal disc up to 3000 revolutions per minute (RPM), a rotation speed suitable for majority of centrifugal microfluidics-based bioassays. For controlling the rotational speed without the need for external circuitry, a combination of magnetic and acoustic tachometry using embedded sensors of the mobile phone was used. Experimentally, the smartphone-based tachometry was proven to be comparable with a standard laser-based tachometer. As a proof of concept, two applications were demonstrated using the portable platform: a colorimetric sandwich immunoassay to detect interleukin-2 (IL-2) and a fully automated measurement of hematocrit level integrating blood-plasma separation, imaging and image analysis. The low-cost platform weighing less than 150 grams operated by a mobile phone has the potential to meet the REASSURED criteria for advanced diagnostics in resource limited settings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- centrifugal microfluidic
- colorimetry
- point-of-care diagnostics
- resource limited settings
- Biotechnology
- Bioteknologi
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)