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Elucidating the Int...
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
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- Kotliar, Ilana B. (författare)
- Rockefeller Univ, Lab Chem Biol & Signal Transduct, New York, NY USA.;Triinst PhD Program Chem Biol, New York, NY USA.
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- Lorenzen, Emily (författare)
- Rockefeller Univ, Lab Chem Biol & Signal Transduct, New York, NY USA.
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH)
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- Hay, Debbie L. (författare)
- Univ Otago, Sch Biomed Sci, Dept Pharmacol & Toxicol, Div Hlth Sci, Dunedin, New Zealand.
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- Sakmar, Thomas P. (författare)
- Karolinska Institutet
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Rockefeller Univ, Lab Chem Biol & Signal Transduct, New York, NY USA;Triinst PhD Program Chem Biol, New York, NY USA. Rockefeller Univ, Lab Chem Biol & Signal Transduct, New York, NY USA. (creator_code:org_t)
- 2022-12-08
- 2023
- Engelska.
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Ingår i: Pharmacological Reviews. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0031-6997 .- 1521-0081. ; 75:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- G protein-coupled receptors (GPCRs) are known to interact with several other classes of integral membrane proteins that modulate their biology and pharmacology. However, the extent of these interactions and the mechanisms of their effects are not well understood. For example, one class of GPCR-interacting proteins, receptor activity-modifying proteins (RAMPs), comprise three related and ubiquitously expressed single-transmembrane span proteins. The RAMP family was discovered more than two decades ago, and since then GPCR-RAMP interactions and their functional consequences on receptor trafficking and ligand selectivity have been documented for several secretin (class B) GPCRs, most notably the calcitonin receptor-like receptor. Recent bioinformatics and multiplexed experimental studies suggest that GPCR-RAMP interactions might bemuchmore widespread than previously anticipated. Recently, cryo-electron microscopy has provided high-resolution structures of GPCR-RAMP-ligand complexes, and drugs have been developed that target GPCR-RAMP complexes. In this review, we provide a summary of recent advances in techniques that allow the discovery of GPCR-RAMP interactions and their functional consequences and highlight prospects for future advances. We also provide an up-to-date list of reported GPCR-RAMP interactions based on a review of the current literature.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
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