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Early fate bias in ...
Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis
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- von Berlin, Leonie (författare)
- Karolinska Institutet
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- Orzechowski Westholm, Jakub (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Solna, Sweden
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- Ratz, Michael (författare)
- Karolinska Institutet,KTH,Genteknologi,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; KTH Royal Institute of Technology, Department of Gene Technology, Stockholm, Sweden
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- Frisén, Jonas (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-12-05
- 2023
- Engelska.
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Ingår i: Hippocampus. - : Wiley. - 1050-9631 .- 1098-1063. ; 33:4, s. 391-401
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Hippocampal adult neural stem cells emerge from progeny of the neuroepithelial lineage during murine brain development. Hippocampus development is increasingly well understood. However, the clonal relationships between early neuroepithelial stem cells and postnatal neurogenic cells remain unclear, especially at the single-cell level. Here we report fate bias and gene expression programs in thousands of clonally related cells in the juvenile hippocampus based on single-cell RNA-seq of barcoded clones. We find evidence for early fate restriction of neuroepithelial stem cells to either neurogenic progenitor cells of the dentate gyrus region or oligodendrogenic, non-neurogenic fate supplying cells for other hippocampal regions including gray matter areas and the Cornu ammonis region 1/3. Our study provides new insights into the phenomenon of early fate restriction guiding the development of postnatal hippocampal neurogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- clonal relationships
- fate choice
- fate specification
- neuroepithelial precursors
- neuroepithelial stem cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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