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Sökning: onr:"swepub:oai:DiVA.org:kth-330099" > A Microfluidic Cont...

A Microfluidic Contact Lens to Address Contact Lens-Induced Dry Eye

Zhu, Yangzhi (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
Nasiri, Rohollah (författare)
KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab,Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
Davoodi, Elham (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
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Zhang, Shiming (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China
Saha, Sourav (författare)
CooperVision Inc., Pleasanton, CA, 94588, USA
Linn, Matthew (författare)
CooperVision Inc., Pleasanton, CA, 94588, USA
Jiang, Lu (författare)
CooperVision Inc., Pleasanton, CA, 94588, USA
Haghniaz, Reihaneh (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
Hartel, Martin C. (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA; Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA
Jucaud, Vadim (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
Dokmeci, Mehmet R. (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
Herland, Anna (författare)
Karolinska Institutet,KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
Toyserkani, Ehsan (författare)
Multi-scale Additive Manufacturing Laboratory, Department of Mechanical and Mechatronics Engineering, University of Waterloo, Ontario, N2L 3G1, Canada
Khademhosseini, Ali (författare)
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA
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 (creator_code:org_t)
2022-12-23
2023
Engelska.
Ingår i: Small. - : Wiley. - 1613-6810 .- 1613-6829. ; 19:11
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The contact lens (CL) industry has made great strides in improving CL-wearing experiences. However, a large amount of CL wearers continue to experience ocular dryness, known as contact lens-induced dry eye (CLIDE), stemming from the reduction in tear volume, tear film instability, increased tear osmolarity followed by inflammation and resulting in ocular discomfort and visual disturbances. In this article, to address tear film thinning between the CL and the ocular surface, the concept of using a CL with microchannels to deliver the tears from the pre-lens tear film (PrLTF) to the post-lens ocular surface using in vitro eye-blink motion is investigated. This study reports an eye-blink mimicking system with microfluidic poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogel with integrated microchannels to demonstrate eye-blink assisted flow through microchannels. This in vitro experimental study provides a proof-of-concept result that tear transport from PrLTF to post-lens tear film can be enhanced by an artificial eyelid motion in a pressure range of 0.1–5 kPa (similar to human eyelid pressure) through poly(HEMA) microchannels. Simulation is conducted to support the hypothesis. This work demonstrates the feasibility of developing microfluidic CLs with the potential to help prevent or minimize CLIDE and discomfort by the enhanced transport of pre-lens tears to the post-lens ocular surface.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

Nyckelord

contact lens-induced dry eyes
microchannels
microfluidic
ocular healthcare
smart contact lenses

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