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Systems-level tempo...
Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection
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- Ambikan, Anoop T. (författare)
- Karolinska Institutet
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Elaldi, Nazif (författare)
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Svensson-Akusjärvi, Sara (författare)
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Bagci, Binnur (författare)
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Pektas, Ayse Nur (författare)
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- Hewson, Roger (författare)
- United Kingdom Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom
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Bagci, Gokhan (författare)
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Arasli, Mehmet (författare)
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Appelberg, Sofia (författare)
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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Sood, Vikas (författare)
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- Végvári, Ákos (författare)
- Karolinska Institutet
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Benfeitas, Rui (författare)
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- Gupta, Soham (författare)
- Karolinska Institutet
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Cetin, Ilhan (författare)
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- Mirazimi, Ali (författare)
- Karolinska Institutet
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- Neogi, Ujjwal (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Proceedings of the National Academy of Sciences, 2023
- 2023
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 120:37
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Crimean-Congo hemorrhagic fever (CCHF) caused by CCHF virus (CCHFV) is one of the epidemic-prone diseases prioritized by the World Health Organisation as public health emergency with an urgent need for accelerated research. The trajectory of host response against CCHFV is multifarious and remains unknown. Here, we reported the temporal spectrum of pathogenesis following the CCHFV infection using genome-wide blood transcriptomics analysis followed by advanced systems biology analysis, temporal immune-pathogenic alterations, and context-specific progressive and postinfection genome-scale metabolic models (GSMM) on samples collected during the acute (T0), early convalescent (T1), and convalescent-phase (T2). The interplay between the retinoic acid-inducible gene-I-like/nucleotide-binding oligomerization domain-like receptor and tumor necrosis factor signaling governed the trajectory of antiviral immune responses. The rearrangement of intracellular metabolic fluxes toward the amino acid metabolism and metabolic shift toward oxidative phosphorylation and fatty acid oxidation during acute CCHFV infection determine the pathogenicity. The upregulation of the tricarboxylic acid cycle during CCHFV infection, compared to the noninfected healthy control and between the severity groups, indicated an increased energy demand and cellular stress. The upregulation of glycolysis and pyruvate metabolism potentiated energy generation through alternative pathways associated with the severity of the infection. The downregulation of metabolic processes at the convalescent phase identified by blood cell transcriptomics and single-cell type proteomics of five immune cells (CD4+ and CD8+ T cells, CD14+ monocytes, B cells, and NK cells) potentially leads to metabolic rewiring through the recovery due to hyperactivity during the acute phase leading to post-viral fatigue syndrome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Crimean-Congo hemorrhagic fever virus
- genome-scale metabolic models
- post viral fatigue
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Till lärosätets databas
- Av författaren/redakt...
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Ambikan, Anoop T ...
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Elaldi, Nazif
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Svensson-Akusjär ...
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Bagci, Binnur
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Pektas, Ayse Nur
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Hewson, Roger
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visa fler...
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Bagci, Gokhan
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Arasli, Mehmet
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Appelberg, Sofia
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Mardinoglu, Adil
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Sood, Vikas
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Végvári, Ákos
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Benfeitas, Rui
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Gupta, Soham
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Cetin, Ilhan
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Mirazimi, Ali
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Neogi, Ujjwal
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Proceedings of t ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet