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Autoantibody Profil...
Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis
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- Mescia, Federica (författare)
- Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK;; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK, Cambridge Biomedical Campus; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy
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- Bayati, Shaghayegh (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Brouwer, Elisabeth (författare)
- Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands
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- Heeringa, Peter (författare)
- Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands;
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- Toonen, Erik J.M. (författare)
- R&D Department, Hycult Biotech, Uden, 5405 PB, The Netherlands
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- Beenes, Marijke (författare)
- R&D Department, Hycult Biotech, Uden, 5405 PB, The Netherlands
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- Ball, Miriam J. (författare)
- Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria;
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- Rees, Andrew J. (författare)
- Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria;
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- Kain, Renate (författare)
- Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria;
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- Lyons, Paul A. (författare)
- Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK;; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK, Cambridge Biomedical Campus
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- Nilsson, Peter (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Pin, Elisa (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 24:20
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- ANCA-associated vasculitides (AAV) are rare autoimmune diseases causing inflammation and damage to small blood vessels. New autoantibody biomarkers are needed to improve the diagnosis and treatment of AAV patients. In this study, we aimed to profile the autoantibody repertoire of AAV patients using in-house developed antigen arrays to identify previously unreported antibodies linked to the disease per se, clinical subgroups, or clinical activity. A total of 1743 protein fragments representing 1561 unique proteins were screened in 229 serum samples collected from 137 AAV patients at presentation, remission, and relapse. Additionally, serum samples from healthy individuals and patients with other type of vasculitis and autoimmune-inflammatory conditions were included to evaluate the specificity of the autoantibodies identified in AAV. Autoreactivity against members of the kinesin protein family were identified in AAV patients, healthy volunteers, and disease controls. Anti-KIF4A antibodies were significantly more prevalent in AAV. We also observed possible associations between anti-kinesin antibodies and clinically relevant features within AAV patients. Further verification studies will be needed to confirm these findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- ANCA-associated vasculitis
- autoantibody profiling
- biomarkers
- kinesins
- protein array
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Mescia, Federica
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Bayati, Shaghaye ...
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Brouwer, Elisabe ...
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Heeringa, Peter
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Toonen, Erik J.M ...
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Beenes, Marijke
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visa fler...
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Ball, Miriam J.
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Rees, Andrew J.
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Kain, Renate
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Lyons, Paul A.
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Nilsson, Peter
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Pin, Elisa
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visa färre...
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