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Longitudinal Relati...
Longitudinal Relationships Between Proteomics and Beta-Cell Dysfunction in Type 2 Diabetes: an IMI Direct Study
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- Rossi, C. A. (författare)
- Institute of Neuroscience, CNR, Padua, Italy
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- Viñuela, A. (författare)
- Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle, UK
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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visa fler...
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- Pearson, E. R. (författare)
- School of Medicine, University of Dundee, Dundee, UK
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- Mari, A. (författare)
- Institute of Neuroscience, CNR, Padua, Italy
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- Bizzotto, R. (författare)
- Institute of Neuroscience, CNR, Padua, Italy
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visa färre...
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(creator_code:org_t)
- Patron Editore S.r.l. 2023
- 2023
- Engelska.
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Ingår i: 8th National Congress of Bioengineering, GNB 2023. - : Patron Editore S.r.l..
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- β-cell dysfunction is a crucial factor of glycaemic deterioration in type 2 diabetes (T2D), but the role of circulating proteins in its progression is currently not understood. We studied the potential associations between β-cell glucose sensitivity progression over 3 years and baseline proteomics in a cohort of recently diagnosed T2D patients (N = 653) from the IMI-DIRECT project, through linear regression analysis. We found that forty-six proteins have a significant association to β-cell glucose sensitivity progression. Subsequent functional analysis showed these proteins belong to functional modules linked to insulin secretion and T2D pathophysiology. These findings, along with further investigation in longitudinal studies, may point to novel protein markers and processes of β-cell function deterioration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- glucose sensitivity
- proteomics
- T2D
- β-cell function
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)