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Remodeling of the h...
Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training
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- Emanuelsson, Eric B. (författare)
- Karolinska Institutet
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- Arif, Muhammad (författare)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Reitzner, Stefan M. (författare)
- Karolinska Institutet
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- Perez, Sean (författare)
- Department of Biology, Pomona College, Claremont, CA 91711, USA
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- Lindholm, Maléne E. (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London WC2R 2LS, UK
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- Daub, Carsten (författare)
- Karolinska Institutet
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- Sundberg, Carl Johan (författare)
- Karolinska Institutet
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- Chapman, Mark A. (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Integrated Engineering, University of San Diego, San Diego, CA 92110, USA
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(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
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Ingår i: iScience. - : Elsevier BV. - 2589-0042. ; 27:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Exercise training has tremendous systemic tissue-specific health benefits, but the molecular adaptations to long-term exercise training are not completely understood. We investigated the skeletal muscle proteome of highly endurance-trained, strength-trained, and untrained individuals and performed exercise- and sex-specific analyses. Of the 6,000+ proteins identified, >650 were differentially expressed in endurance-trained individuals compared with controls. Strikingly, 92% of the shared proteins with higher expression in both the male and female endurance groups were known mitochondrial. In contrast to the findings in endurance-trained individuals, minimal differences were found in strength-trained individuals and between females and males. Lastly, a co-expression network and comparative literature analysis revealed key proteins and pathways related to the health benefits of exercise, which were primarily related to differences in mitochondrial proteins. This network is available as an interactive database resource where investigators can correlate clinical data with global gene and protein expression data for hypothesis generation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Biological sciences
- Health sciences
- Medicine
- Omics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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