Sökning: onr:"swepub:oai:DiVA.org:kth-34405" > In vitro and in viv...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04305naa a2200517 4500 | |
001 | oai:DiVA.org:kth-34405 | |
003 | SwePub | |
008 | 110607s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344052 URI |
024 | 7 | a https://doi.org/10.1016/j.actbio.2011.02.0112 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dånmark, Staffanu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1rvvxzs |
245 | 1 0 | a In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization |
264 | 1 | b Elsevier BV,c 2011 |
338 | a print2 rdacarrier | |
500 | a QC 20150727 | |
520 | a Degradation characteristics in response to electron beam sterilization of designed and biodegradable aliphatic polyester scaffolds are relevant for clinically successful synthetic graft tissue regeneration Scaffold degradation in vitro and in vivo were documented and correlated to the macroscopic structure and chemical design of the original polymer The materials tested were of inherently diverse hydrophobicity and crystallinity poly(L-lactide) (poly(LLA)) and random copolymers from L-lactide and epsilon-caprolactone or 1.5-dioxepan-2-one, fabricated into porous and non-porous scaffolds After sterilization, the samples underwent hydrolysis in vitro for up to a year In vivo, scaffolds were surgically implanted into rat calvarial defects and retrieved for analysis after 28 and 91 days In vitro, poly(L-lactide-co-1, 5-dioxepan-2-one) (poly(LLA-co-DXO)) samples degraded most rapidly during hydrolysis, due to the pronounced chain-shortening reaction caused by the sterilization. This was indicated by the rapid decrease in both mass and molecular weight of poly(LLA-co-DXO). Poly(L-lactide-co-epsilon-caprolactone) (poly(LLA-co-CL)) samples were also strongly affected by sterilization, but mass loss was more gradual; molecular weight decreased rapidly during hydrolysis Least affected by sterilization were the poly(LLA) samples, which subsequently showed low mass loss rate and molecular weight decrease during hydrolysis. Mechanical stability varied greatly. poly(LLA-co-CL) withstood mechanical testing for up to 182 days, while poly(LLA) and poly(LLA-co-DXO) samples quickly became too brittle Poly(LLA-co-DXO) samples unexpectedly degraded more rapidly in vitro than in vivo. After sterilization by electron beam irradiation, the three biodegradable polymers present widely diverse degradation profiles, both in vitro and in vivo. Each exhibits the potential to be tailored to meet diverse clinical tissue engineering requirements | |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Industriell bioteknikx Annan industriell bioteknik0 (SwePub)209992 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Industrial Biotechnologyx Other Industrial Biotechnology0 (SwePub)209992 hsv//eng |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Materialteknik0 (SwePub)2052 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Materials Engineering0 (SwePub)2052 hsv//eng |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Kemiteknikx Polymerteknologi0 (SwePub)204032 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Chemical Engineeringx Polymer Technologies0 (SwePub)204032 hsv//eng |
653 | a Aliphatic polyesters | |
653 | a Electron beam sterilization | |
653 | a Degradation | |
653 | a Tissue engineering | |
653 | a Scaffolds | |
653 | a Other bioengineering | |
653 | a | |
653 | a Materials science | |
653 | a Teknisk materialvetenskap | |
700 | 1 | a Finne-Wistrand, Annau KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u17gwfv7 |
700 | 1 | a Schander, K.4 aut |
700 | 1 | a Hakkarainen, Minnau KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u14e229n |
700 | 1 | a Arvidson, K.4 aut |
700 | 1 | a Mustafa, K.4 aut |
700 | 1 | a Albertsson, Ann-Christineu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1mpsp3u |
710 | 2 | a KTHb Fiber- och polymerteknologi4 org |
773 | 0 | t ACTA BIOMATERIALIAd : Elsevier BVg 7:5, s. 2035-2046q 7:5<2035-2046x 1742-7061 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-34405 |
856 | 4 8 | u https://doi.org/10.1016/j.actbio.2011.02.011 |
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