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Sökning: onr:"swepub:oai:DiVA.org:kth-347674" > Peripheral Blood Mo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004746naa a2200625 4500
001oai:DiVA.org:kth-347674
003SwePub
008240613s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3476742 URI
0247 a https://doi.org/10.1513/AnnalsATS.202305-417OC2 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Buschur, Kristina L.4 aut
2451 0a Peripheral Blood Mononuclear Cell Gene Expression Associated with Pulmonary Microvascular Perfusion: The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease
264 1b American Thoracic Society,c 2024
338 a print2 rdacarrier
500 a QC 20240617
520 a Rationale: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with endothelial damage and altered pulmonary microvascular perfusion. The molecular mechanisms underlying these changes are poorly understood in patients, in part because of the inaccessibility of the pulmonary vasculature. Peripheral blood mononuclear cells (PBMCs) interact with the pulmonary endothelium. Objectives: To test the association between gene expression in PBMCs and pulmonary microvascular perfusion in COPD. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited two independent samples of COPD cases and controls with ⩾10 pack-years of smoking history. In both samples, pulmonary microvascular blood flow, pulmonary microvascular blood volume, and mean transit time were assessed on contrast-enhanced magnetic resonance imaging, and PBMC gene expression was assessed by microarray. Additional replication was performed in a third sample with pulmonary microvascular blood volume measures on contrast-enhanced dual-energy computed tomography. Differential expression analyses were adjusted for age, gender, race/ethnicity, educational attainment, height, weight, smoking status, and pack-years of smoking. Results: The 79 participants in the discovery sample had a mean age of 69 ± 6 years, 44% were female, 25% were non-White, 34% were current smokers, and 66% had COPD. There were large PBMC gene expression signatures associated with pulmonary microvascular perfusion traits, with several replicated in the replication sets with magnetic resonance imaging (n = 47) or dual-energy contrast-enhanced computed tomography (n = 157) measures. Many of the identified genes are involved in inflammatory processes, including nuclear factor-κB and chemokine signaling pathways. Conclusions: PBMC gene expression in nuclear factor-κB, inflammatory, and chemokine signaling pathways was associated with pulmonary microvascular perfusion in COPD, potentially offering new targetable candidates for novel therapies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a COPD
653 a gene expression
653 a pulmonary microvascular perfusion
7001 a Pottinger, Tess D.4 aut
7001 a Vogel-Claussen, Jens4 aut
7001 a Powell, Charles A.u Mount Sinai Hospital4 aut
7001 a Aguet, Francois4 aut
7001 a Allen, Norrina B.4 aut
7001 a Ardlie, Kristin4 aut
7001 a Bluemke, David A.4 aut
7001 a Durda, Peter4 aut
7001 a Hermann, Emilia A.4 aut
7001 a Hoffman, Eric A.4 aut
7001 a Lima, João A.C.4 aut
7001 a Liu, Yongmei4 aut
7001 a Malinsky, Daniel4 aut
7001 a Manichaikul, Ani4 aut
7001 a Motahari, Amin4 aut
7001 a Post, Wendy S.4 aut
7001 a Prince, Martin R.4 aut
7001 a Rich, Stephen S.4 aut
7001 a Rotter, Jerome I.4 aut
7001 a Smith, Benjamin M.4 aut
7001 a Tracy, Russell P.4 aut
7001 a Watson, Karolu Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California; and4 aut
7001 a Winther, Hinrich B.4 aut
7001 a Lappalainen, Tuuliu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1o81n30
7001 a Barr, R. Graham4 aut
7102 a Mount Sinai Hospitalb Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California; and4 org
7730 t Annals of the American Thoracic Societyd : American Thoracic Societyg 21:6, s. 884-894q 21:6<884-894x 2329-6933x 2325-6621
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-347674
8564 8u https://doi.org/10.1513/AnnalsATS.202305-417OC

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