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Screening for Circu...
Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus
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- Cederroth, Christopher R. (författare)
- Karolinska Institutet
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- Hong, Mun-Gwan, 1976- (författare)
- Stockholms universitet,KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Stockholm University, Stockholm, Sweden,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),KTH Royal Institute of Technology, Sweden
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- Freydin, Maxim B. (författare)
- Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London, London, UK
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- Edvall, Niklas K. (författare)
- Karolinska Institutet
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- Trpchevska, Natalia (författare)
- Section of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
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- Jarach, Carlotta (författare)
- Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
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- Schlee, Winfried (författare)
- Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
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- Schwenk, Jochen M. (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Stockholm University, Stockholm, Sweden
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- Lopez-Escamez, Jose Antonio (författare)
- Faculty of Medicine & Health, School of Medical Sciences, Meniere’s Disease Neuroscience Research Program, The Kolling Institute, University of Sydney, Sydney, NSW, Australia; Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO - Centre for Genomics and Oncological Research - Pfizer, University of Granada, PTS, Junta de Andalucía, Granada, Spain, Junta de Andalucía; Division of Otolaryngology, Department of Surgery, Instituto de Investigación Biosanitaria, ibs.GRANADA, Universidad de Granada, GranadaGranada, Spain
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- Gallus, Silvano (författare)
- Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
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- Canlon, Barbara (författare)
- Karolinska Institutet
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- Bulla, Jan (författare)
- Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; Department of Mathematics, University of Bergen, Bergen, Norway
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- Williams, Frances M.K. (författare)
- Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King’s College London, London, UK
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Journal of the Association for Research in Otolaryngology. - : Springer Nature. - 1525-3961 .- 1438-7573. ; 24:6, s. 593-606
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and Objective: Tinnitus would benefit from an objective biomarker. The goal of this study is to identify plasma biomarkers of constant and chronic tinnitus among selected circulating inflammatory proteins. Methods: A case–control retrospective study on 548 cases with constant tinnitus and 548 matched controls from the Swedish Tinnitus Outreach Project (STOP), whose plasma samples were examined using Olink’s Inflammatory panel. Replication and meta-analysis were performed using the same method on samples from the TwinsUK cohort. Participants from LifeGene, whose blood was collected in Stockholm and Umeå, were recruited to STOP for a tinnitus subtyping study. An age and sex matching was performed at the individual level. TwinsUK participants (n = 928) were selected based on self-reported tinnitus status over 2 to 10 years. Primary outcomes include normalized levels for 96 circulating proteins, which were used as an index test. No reference standard was available in this study. Results: After adjustment for age, sex, BMI, smoking, hearing loss, and laboratory site, the top proteins identified were FGF-21, MCP4, GDNF, CXCL9, and MCP-1; however, these were no longer statistically significant after correction for multiple testing. Stratification by sex did not yield any significant associations. Similarly, associations with hearing loss or other tinnitus-related comorbidities such as stress, anxiety, depression, hyperacusis, temporomandibular joint disorders, and headache did not yield any significant associations. Analysis in the TwinsUK failed in replicating the top candidates. Meta-analysis of STOP and TwinsUK did not reveal any significant association. Using elastic net regularization, models exhibited poor predictive capacity tinnitus based on inflammatory markers [sensitivity = 0.52 (95% CI 0.47–0.57), specificity = 0.53 (0.48–0.58), positive predictive value = 0.52 (0.47–0.56), negative predictive values = 0.53 (0.49–0.58), and AUC = 0.53 (0.49–0.56)]. Discussion: Our results did not identify significant associations of the selected inflammatory proteins with constant tinnitus. Future studies examining longitudinal relations among those with more severe tinnitus and using more recent expanded proteomics platforms and sampling of cerebrospinal fluid could increase the likelihood of identifying relevant molecular biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- Auditory
- Biomarker
- Constant
- Diagnostic
- Olink
- Plasma
- Profiling
- Tinnitus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cederroth, Chris ...
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Hong, Mun-Gwan, ...
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Freydin, Maxim B ...
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Edvall, Niklas K ...
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Trpchevska, Nata ...
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Jarach, Carlotta
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Schlee, Winfried
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Schwenk, Jochen ...
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Lopez-Escamez, J ...
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Gallus, Silvano
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Canlon, Barbara
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Bulla, Jan
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Williams, France ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Oto rhino laryng ...
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Journal of the A ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Stockholms universitet
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Karolinska Institutet