Sökning: onr:"swepub:oai:DiVA.org:kth-350188" > Synthesis, Characte...
Fältnamn | Indikatorer | Metadata |
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000 | 04049naa a2200445 4500 | |
001 | oai:DiVA.org:kth-350188 | |
003 | SwePub | |
008 | 240708s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3501882 URI |
024 | 7 | a https://doi.org/10.1080/10406638.2023.22762432 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Akbas, Esvetu Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye4 aut |
245 | 1 0 | a Synthesis, Characterization, Theoretical Studies and in Vitro Embriyotoxic, Genotoxic and Anticancer Effects of Novel Phenyl(1,4,6-Triphenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidin-5-yl)Methanone |
264 | c 2023 | |
264 | 1 | b Informa UK Limited,c 2023 |
338 | a print2 rdacarrier | |
500 | a QC 20240708 | |
520 | a In this study, phenyl (1,4,6-triphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methanone was obtained by using the Biginelli reaction method. The structure of this compound was analyzed using elemental analysis, IR, 1H, and 13C NMR. The quantum chemical calculations (QCC) of this compound were performed density functional theory (DFT) method, 6–31 G (d, p) base set, and B3LYP functions with the Gaussian09W software package. Literature shows that pyrimidine-derived compounds have very active biological properties. For this reason, the biologically active properties of the synthesized compound were also examined. To determine embryotoxic, genotoxic, and cytotoxic effects of compound, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), lactate dehydrogenase (LDH) release, micronucleus (MN) and 8-OH-dG assays were carried out. On the other hand, pharmacokinetic and toxicity properties (ADMET) were predicted in silico via SwissADME and Protox-II web tools. In silico estimates of this compound used in the study showed that the compound has the covetable physicochemical properties for bioavailability. In conclusion, the obtained results of our study clearly showed that this compound exerted strong toxicity potential. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
653 | a cytotoxicity | |
653 | a DFT | |
653 | a embryotoxicity | |
653 | a genotoxicity | |
653 | a Pyrimidin | |
653 | a theoretical chemistry | |
700 | 1 | a Othman, Khdir A.u Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye; Faculty of science and health, Department of chemistry, Koya University, Koy Sanjaq, Iraq4 aut |
700 | 1 | a Çelikezen, Fatih Çağlaru Bitlis Eren University Faculty of Science and Letter, Department of Chemistry, Bitlis, Turkey4 aut |
700 | 1 | a Aydogan Ejder, Nebahatu Department of Medical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey4 aut |
700 | 1 | a Turkez, Hasanu Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey4 aut |
700 | 1 | a Yapca, Omer Erkanu Department of Obstetrics and Gynecology, Atatürk University Faculty of Medicine, Erzurum, Turkey4 aut |
700 | 1 | a Mardinoglu, Adilu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UK4 aut0 (Swepub:kth)u1t8kmr6 |
710 | 2 | a Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiyeb Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye; Faculty of science and health, Department of chemistry, Koya University, Koy Sanjaq, Iraq4 org |
773 | 0 | t Polycyclic aromatic compounds (Print)d : Informa UK Limitedg , s. 1-18q <1-18x 1040-6638x 1563-5333 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-350188 |
856 | 4 8 | u https://doi.org/10.1080/10406638.2023.2276243 |
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