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Molecular Structura...
Molecular Structural Differences between Type-2-Diabetic and Healthy Glycogen
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- Sullivan, Mitchell A. (författare)
- The University of Queensland
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- Li, Jiong (författare)
- Wuhan University
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- Li, Chuanzhou (författare)
- Wuhan University
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- Vilaplana, Francisco (författare)
- The University of Queensland
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- Stapleton, David (författare)
- University of Melbourne
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- Gray-Weale, Angus A. (författare)
- Monash University
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- Bowen, Stirling (författare)
- Southern Cross University
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- Zheng, Ling (författare)
- Wuhan University
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- Gilbert, Robert G. (författare)
- The University of Queensland
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(creator_code:org_t)
- 2011-05-19
- 2011
- Engelska.
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Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 12:6, s. 1983-1986
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically del;ranched) as a function of molecular size, isolated from the liver; of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more a particles (tightly linked assemblages of smaller,8 particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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