Sökning: onr:"swepub:oai:DiVA.org:kth-50439" >
Extrapolating tradi...
-
Royce, Thomas E.
(författare)
Extrapolating traditional DNA microarray statistics to tiling and protein microarray technologies
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:kth-50439
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50439URI
-
https://doi.org/10.1016/S0076-6879(06)11015-0DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
QC 20111207
-
A credit to microarray technology is its broad application. Two experiments--the tiling microarray experiment and the protein microarray experiment--are exemplars of the versatility of the microarrays. With the technology's expanding list of uses, the corresponding bioinformatics must evolve in step. There currently exists a rich literature developing statistical techniques for analyzing traditional gene-centric DNA microarrays, so the first challenge in analyzing the advanced technologies is to identify which of the existing statistical protocols are relevant and where and when revised methods are needed. A second challenge is making these often very technical ideas accessible to the broader microarray community. The aim of this chapter is to present some of the most widely used statistical techniques for normalizing and scoring traditional microarray data and indicate their potential utility for analyzing the newer protein and tiling microarray experiments. In so doing, we will assume little or no prior training in statistics of the reader. Areas covered include background correction, intensity normalization, spatial normalization, and the testing of statistical significance.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Rozowsky, Joel S.
(författare)
-
Luscombe, Nicholas M.
(författare)
-
Emanuelsson, OlofYale University(Swepub:kth)u15t3py5
(författare)
-
Yu, Haiyuan
(författare)
-
Zhu, Xiaowei
(författare)
-
Snyder, Michael
(författare)
-
Gerstein, Mark B.
(författare)
-
Yale University
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Methods in Enzymology411, s. 282-3110076-68791557-7988
Internetlänk
Hitta via bibliotek
Till lärosätets databas