The Human Protein Atlas as a proteomic resource for biomarker discovery

Pontén, FredrikUppsala universitet,Molekylär och morfologisk patologi,Pontén (författare)

QC 20111212
The analysis of tissue-specific expression at both the gene and protein levels is vital for understanding human biology and disease. Antibody-based proteomics provides a strategy for the systematic generation of antibodies against all human proteins to combine with protein profiling in tissues and cells using tissue microarrays, immunohistochemistry and immunofluorescence. The Human Protein Atlas project was launched in 2003 with the aim of creating a map of protein expression patterns in normal cells, tissues and cancer. At present, 11 200 unique proteins corresponding to over 50% of all human protein encoding genes have been analysed. All protein expression data, including underlying high-resolution images, are published on the free and publically available Human Protein Atlas portal (http://www.proteinatlas.org). This database provides an important source of information for numerous biomedical research projects, including biomarker discovery efforts. Moreover, the global analysis of how our genome is expressed at the protein level has provided basic knowledge on the ubiquitous expression of a large proportion of our proteins and revealed the paucity of cell-andtissue-type-specific proteins.

Schwenk, Jochen M.KTH,Proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1h7wtme (författare)
Asplund, AnnaUppsala universitet,Molekylär och morfologisk patologi,Pontén(Swepub:uu)annaaspl (författare)
Edqvist, Per-Henrik D.Uppsala universitet,Molekylär och morfologisk patologi,Pontén(Swepub:uu)peedq227 (författare)
Uppsala universitetMolekylär och morfologisk patologi (creator_code:org_t)

Av författaren/redakt...: Pontén, Fredrik; Schwenk, Jochen ...; Asplund, Anna; Edqvist, Per-Hen ...

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