GABAergic control of backpropagating action potentials in striatal medium spiny neurons

QC 20120119
Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites[1-3]. Increased calcium levels trigger changes in plasticity[4,5], which is important for learning and other functions[6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites[7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of these GABAergic inputs on the dendritic calcium dynamics is investigated.

Zilberter, M (författare)
Oliveria, R.F. (författare)
Blackwell, Kim T. (författare)
Hellgren Kotaleski, JeanetteKTH,Beräkningsbiologi, CB(Swepub:kth)u13pnwqn (författare)
KTHBeräkningsbiologi, CB (creator_code:org_t)

Av författaren/redakt...: Hjorth, Johannes; Zilberter, M; Oliveria, R.F.; Blackwell, Kim T ...; Hellgren Kotales ...

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