Glucose-stimulated insulin secretion - insights from modelling

QC 20111110
Insulin is secreted by the pancreatic β-cells in response to a raised blood glucose concentration. Glucose-stimulated insulin secretion (GSIS) is pulsatile and correlated with bursting electrical activity. We review the current understanding of pancreatic p-cell GSIS from a mathematical modelling perspective. We discuss the glycolysis and the mitochondrial metabolism and metabolic modelling thereof. In particular, we describe the theoretical basis for the hypothesis of an oscillatory glycolysis, which may be the cause of the pulsatile secretion. We also discuss the electrophysiology of the P-cell and present insights gained from mathematical modelling in this context. There are important causal connections between β-cell metabolism and electrophysiology. This brings about an unusual challenge for theoretical and computational biologists.

Hällgren Kotaleski, JeanetteKTH,Numerisk analys och datalogi, NADA(Swepub:kth)u13pnwqn (författare)
Lansner, AndersKTH,Numerisk analys och datalogi, NADA(Swepub:kth)u12s8cr8 (författare)
KTHNumerisk analys och datalogi, NADA (creator_code:org_t)

Av författaren/redakt...: Westermark, Pål; Hällgren Kotales ...; Lansner, Anders

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.