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Role of N-terminal ...
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Govind, Satish C
(författare)
Role of N-terminal pro-brain natriuretic peptide in ST-segment elevation myocardial infarction : experience from a tertiary centre in India.
- Artikel/kapitelEngelska2011
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-78261
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-78261URI
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https://doi.org/10.1097/HPC.0b013e318239651fDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20120217
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BACKGROUND: Role of biomarkers in ST-segment elevation myocardial infarction (STEMI) is paramount, as they aid in diagnosis and gauge prognosis of the disease. In this project, we sought to study the short-term outcome and clinical associates of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the setting of STEMI at a tertiary center in India. METHODS: In all, 173 STEMI patients (mean age: 57 ± 12 years, 38 women) had their NT-proBNP assayed in addition to troponins and high-sensitive C-reactive protein. Subjects were divided according to NT-proBNP levels into 2 groups: group 1 (NT-proBNP ≤100 pg/mL) and group 2 (NT-proBNP >100 pg/mL). RESULTS: NT-proBNP values (pg/mL) were elevated in group 2 (group 1: 61.7 ± 6.2; group 2: 1006.5 ± 990.6, P < 0.0001). Significantly greater number of females had elevated NT-proBNP (P < 0.05) that could be predicted by the duration of chest pain related to STEMI (area under the curve: 0.72), and age at presentation (area under the curve: 0.66). Multiple regression analysis showed a strong inverse association between NT-proBNP and left ventricular ejection fraction and a strong positive association between the peptide and high-sensitive C-reactive protein. A significant positive association was also noted between NT-proBNP and troponin I (all P < 0.05, Global R = 0.47). Diabetes mellitus and/or hypertension, and infarction localization showed no effect on NT-proBNP levels along with death, primary coronary intervention-related bleeding, and arrhythmias, (χ, P = ns). CONCLUSIONS: The data suggest that women are more likely to have increased NT-proBNP while presenting with STEMI. Duration of chest pain and age at presentation are the best predictors of elevated NT-proBNP, though without much bearing on short-term morbidity and mortality.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kiotsekoglou, Anatoli
(författare)
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Gadiyaram, Varuna K
(författare)
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Gopal, Aasha S
(författare)
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Brodin, Lars-ÅkeKTH,Medicinsk teknik(Swepub:kth)u1jq9s27
(författare)
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Ramesh, Saligrama S
(författare)
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Saha, Samir K
(författare)
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KTHMedicinsk teknik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Critical Pathways in Cardiology10:4, s. 180-1841535-282X1535-2811
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