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Subunit arrangement...
Subunit arrangement in the dodecameric chloroplast small heat shock protein Hsp21
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Lambert, W (författare)
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- Koeck, Philip J. B. (författare)
- Department of Bioscience, Karolinska Institutet, Novum, Sweden
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- Åhrman, Emma (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Reumatologi och molekylär skelettbiologi,Institutionen för kliniska vetenskaper, Lund,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Rheumatology,Department of Clinical Sciences, Lund
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- Purhonen, P (författare)
- Karolinska Institutet
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Cheng, K (författare)
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Elmlund, D (författare)
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- Hebert, Hans (författare)
- Karolinska Institutet
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Emanuelsson, C (författare)
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(creator_code:org_t)
- 2010-12-23
- 2011
- Engelska.
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Ingår i: Protein Science. - : Wiley. - 0961-8368 .- 1469-896X. ; 20:2, s. 291-301
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Unfolding proteins are prevented from irreversible aggregation by small heat shock proteins (sHsps) through interactions that depend on a dynamic equilibrium between sHsp subunits and sHsp oligomers. A chloroplast-localized sHsp, Hsp21, provides protection to client proteins to increase plant stress resistance. Structural information is lacking concerning the oligomeric conformation of this sHsp. We here present a structure model of Arabidopsis thaliana Hsp21, obtained by homology modeling, single-particle electron microscopy, and lysine-specific chemical crosslinking. The model shows that the Hsp21 subunits are arranged in two hexameric discs, similar to a cytosolic plant sHsp homolog that has been structurally determined after crystallization. However, the two hexameric discs of Hsp21 are rotated by 25 degrees in relation to each other, suggesting a role for global dynamics in dodecamer function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
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