Sökning: onr:"swepub:oai:DiVA.org:kth-87054" >
Solubility of form ...
-
Maher, AnthonyChemical and Environmental Science, University of Limerick, Ireland
(författare)
Solubility of form III piracetam in a range of solvents
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
-
2010-10-13
-
American Chemical Society (ACS),2010
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:kth-87054
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-87054URI
-
https://doi.org/10.1021/je1003934DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
QC 20120301
-
The polymorph known as Form III of 2-oxo-1-pyrrolidine acetamide (piracetam) was isolated by cooling crystallization from methanol and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Form III is the thermodynamically stable polymorph of piracetam in the range of this solubility study. The solubility of Form III was determined by gravimetrically measuring the amount of Form III which was contained in a volume of saturated solution over the temperature range (278 to 323) K, following evaporation of the solvent. Five solvents were examined: methanol, ethanol, 2-propanol, acetone, and 1,4-dioxane. The results showed that the solubility values correlated positively with solvent polar characteristics from a qualitative point of view; an increase in solubility of Form 111 was observed with increasing solvent polarity and solvent acidity. As the number of carbons in the n-alcohols increases, the polarity of the solvent and its hydrogen donation ability decreases and so does the solubility of Form III in the solvent. 1,4-Dioxane and acetone are relatively nonpolar and non-hydrogen bond donating solvents compared to the n-alcohols, and accordingly Form III is much less soluble in these.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Croker, DeniseChemical and Environmental Science, University of Limerick, Ireland
(författare)
-
Rasmuson, Åke,1952-University of Limerick(Swepub:kth)u1w1ulhl
(författare)
-
Hodnett, KieranChemical and Environmental Science, University of Limerick, Ireland
(författare)
-
Chemical and Environmental Science, University of Limerick, IrelandUniversity of Limerick
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Chemical and Engineering Data: American Chemical Society (ACS)55:11, s. 5314-53180021-95681520-5134
Internetlänk
Hitta via bibliotek
Till lärosätets databas