Sökning: onr:"swepub:oai:DiVA.org:liu-100331" >
Salt-inducible kina...
Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure
-
- Popov, Sergej (författare)
- Karolinska Institutet
-
- Silveira, Angela (författare)
- Karolinska Institutet
-
- Wågsäter, Dick (författare)
- Karolinska University Hospital, Solna, Stockholm, Sweden
-
visa fler...
-
- Takemori, Hiroshi (författare)
- National Institute for Biomedical Innovation, Osaka, Japan
-
- Oguro, Ryousuke (författare)
- Osaka University, Japan
-
- Matsumoto, Sachiko (författare)
- National Cerebral and Cardiovascular Center, Suita, Japan
-
- Sugimoto, Ken (författare)
- Osaka University, Japan
-
- Kamide, Kei (författare)
- Osaka University, Japan
-
- Hirose, Takuo (författare)
- Tohoku University, Sendai, Japan
-
- Satoh, Michihiro (författare)
- Tohoku University, Sendai, Japan
-
- Metoki, Hirohito (författare)
- Tohoku University, Sendai, Japan
-
- Kikuya, Masahiro (författare)
- Tohoku University, Sendai, Japan
-
- Ohkubo, Takayoshi (författare)
- Tohoku University, Sendai, Japan
-
- Katsuya, Tomohiro (författare)
- Osaka University, Japan
-
- Rakugi, Hiromi (författare)
- Osaka University, Japan
-
- Imai, Yutaka (författare)
- Tohoku University, Sendai, Japan
-
- Sanchez, Fabio (författare)
- Karolinska University Hospital, Solna, Stockholm, Sweden
-
- Leosdottir, Margrét (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund University, Sweden
-
- Syvänen, Ann-Christine (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Sweden
-
- Hamsten, Anders (författare)
- Karolinska Institutet
-
- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Sweden
-
- Bertorello, Alejandro M. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Lippincott Williams & Wilkins, 2011
- 2011
- Engelska.
-
Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 29:12, s. 2395-2403
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES:Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential role in regulating the plasma membrane Na(+),K(+)-ATPase. The objective of this study was to examine whether SIK1 is present in vascular smooth muscle cells (VSMCs) and endothelial cells, whether it affects VSMC Na(+),K(+)-ATPase activity and whether human SIK1 (hSIK1) represents a potential candidate for blood pressure regulation.METHODS:Localization of SIK1 was performed using immunohistochemistry, mRNA and western blot. Functional assays (Na(+),K(+)-ATPase activity) were performed in VSMCs derived from rat aorta. Genotype-phenotype association studies were performed in three Swedish and one Japanese population-based cohorts.RESULTS:SIK1 was localized in human VSMCs and endothelial cells, as well as a cell line derived from rat aorta. A nonsynonymous single nucleotide polymorphism in the hSIK1 gene exon 3 (C→T, rs3746951) results in the amino acid change (15)Gly→Ser in the SIK1 protein. SIK1-(15)Ser was found to increase plasma membrane Na(+),K(+)-ATPase activity in cultured VSMC line from rat aorta. Genotype-phenotype association studies in three Swedish and one Japanese population-based cohorts suggested that T allele (coding for (15)Ser) was associated with lower blood pressure (P = 0.005 for SBP and P = 0.002 for DBP) and with a decrease in left ventricular mass (P = 0.048).CONCLUSION:The hSIK1 appears to be of potential relevance within VSMC function and blood pressure regulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- hypertension; Na
- K+-ATPase; salt sensitivity; vascular tonus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Popov, Sergej
-
Silveira, Angela
-
Wågsäter, Dick
-
Takemori, Hirosh ...
-
Oguro, Ryousuke
-
Matsumoto, Sachi ...
-
visa fler...
-
Sugimoto, Ken
-
Kamide, Kei
-
Hirose, Takuo
-
Satoh, Michihiro
-
Metoki, Hirohito
-
Kikuya, Masahiro
-
Ohkubo, Takayosh ...
-
Katsuya, Tomohir ...
-
Rakugi, Hiromi
-
Imai, Yutaka
-
Sanchez, Fabio
-
Leosdottir, Marg ...
-
Syvänen, Ann-Chr ...
-
Hamsten, Anders
-
Melander, Olle
-
Bertorello, Alej ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of Hyper ...
- Av lärosätet
-
Linköpings universitet
-
Uppsala universitet
-
Lunds universitet
-
Karolinska Institutet