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Down-regulation of ...
Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)
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- Wågsäter, Dick (författare)
- University of Örebro, Sweden
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- Sirsjö, Allan (författare)
- University of Örebro, Sweden
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- Dimberg, Jan (författare)
- School of Health Sciences, Jönköping; Sweden
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(creator_code:org_t)
- BioMed Central (BMC), 2003
- 2003
- Engelska.
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Ingår i: Journal of Experimental & Clinical Cancer Research. - : BioMed Central (BMC). - 1756-9966. ; 22:3, s. 471-475
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Abstract
Ämnesord
Stäng
- Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.
Nyckelord
- Id2; all-trans retinoic acid; THP-1 cells; differentiation; proliferation; helix-loop-helix
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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