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The Contribution of...
The Contribution of GJB2 (Connexin 26) 35delG to Age-Related Hearing Impairment and Noise-Induced Hearing Loss
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- Van Eyken, Els (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Fransen, Erik (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Topsakal, Vedat (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Hendrickx, Jan-Jaap (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Demeester, Kelly (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Van de Heyning, Paul (författare)
- Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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- Mäki-Torkko, Elina (författare)
- Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper
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- Hannula, Samuli (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Sorri, Martti (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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- Jensen, Mona (författare)
- Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
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- Parving, Agnete (författare)
- Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
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- Bille, Mikael (författare)
- Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
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- Bauer, Manuela (författare)
- Department of Otorhinolaryngology, University of Tüebingen, Tüebingen, Germany;
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- Pfister, Markus (författare)
- Department of Otorhinolaryngology, University of Tüebingen, Tüebingen, Germany
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- Bonaconsa, Amanda (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Mazzoli, Manuela (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Orzan, Eva (författare)
- Department of Oto-surgery, University Hospital Padova, Padova, Italy
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- Espeso, Angeles (författare)
- Welsh hearing Institute, University Hospital of Wales, Cardiff, U.K.
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- Stephens, Dafydd (författare)
- Welsh hearing Institute, University Hospital of Wales, Cardiff, U.K.
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- Verbruggen, Katia (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Huyghe, Joke (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Dhooge, Ingeborg (författare)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Huygen, Patrick (författare)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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- Kremer, Hannie (författare)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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- Cremers, Cor (författare)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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- Manninen, Minna (författare)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Pyykkö, Ilmari (författare)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Rajkowska, Elzbieta (författare)
- Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
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- Pawelczyk, Malgorzata (författare)
- Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
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- Sliwinska-Kowalska, Mariola (författare)
- Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
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- Steffens, Mikael (författare)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Wienker, Thomas (författare)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Van Camp, Guy (författare)
- University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, the Netherlands
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- Van Laer, Lut (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Kunst, Sylvia (författare)
- Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2007
- 2007
- Engelska.
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Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 28:7, s. 970-975
- Relaterad länk:
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http://www.ncbi.nlm....
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https://journals.lww...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Hypothesis: The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced hearing loss (NIHL).Background: GJB2, a gene encoding a gap junction protein expressed in the inner ear, has been suggested to be involved in the potassium recycling pathway in the cochlea. GJB2 mutations account for a large number of individuals with nonsyndromic recessive hearing loss, with 35delG being the most frequent mutation in populations of European origin. Other genes involved in potassium homeostasis have been suggested to be associated with ARHI and NIHL, and distortion product otoacoustic emission distortions indicative of hearing loss alterations have been found in 35delG carriers.Method: We genotyped 35delG in two distinct sample sets: an ARHI sample set, composed of 2,311 Caucasian samples from nine different centers originating from seven different countries with an age range between 53 and 67 years, and an NIHL sample set consisting of 702 samples from the two extremes of a noise-exposed Polish sample.Results: After statistical analysis, we were unable to detect an association between 35delG and ARHI, nor between 35delG and NIHL.Conclusion: Our findings indicate that there is no increased susceptibility in 35delG carriers for the development of ARHI or NIHL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- 35delG
- Age-related hearing impairment
- Complex disorder
- Noise-induced hearing loss
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Van Eyken, Els
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Fransen, Erik
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Topsakal, Vedat
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Hendrickx, Jan-J ...
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Demeester, Kelly
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Van de Heyning, ...
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visa fler...
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Mäki-Torkko, Eli ...
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Hannula, Samuli
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Sorri, Martti
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Jensen, Mona
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Parving, Agnete
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Bille, Mikael
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Bauer, Manuela
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Pfister, Markus
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Bonaconsa, Amand ...
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Mazzoli, Manuela
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Orzan, Eva
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Espeso, Angeles
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Stephens, Dafydd
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Verbruggen, Kati ...
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Huyghe, Joke
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Dhooge, Ingeborg
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Huygen, Patrick
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Kremer, Hannie
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Cremers, Cor
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Manninen, Minna
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Pyykkö, Ilmari
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Rajkowska, Elzbi ...
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Pawelczyk, Malgo ...
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Sliwinska-Kowals ...
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Steffens, Mikael
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Wienker, Thomas
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Van Camp, Guy
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Van Laer, Lut
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Kunst, Sylvia
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oto rhino laryng ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Otology and Neur ...
- Av lärosätet
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Linköpings universitet
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Örebro universitet