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Circulating Anti-Gl...
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Ohlsson, SophieSkåne University Hospital, Sweden
(författare)
Circulating Anti-Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti-Glomerular Basement Membrane Disease
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Elsevier,2014
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-104282
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104282URI
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https://doi.org/10.1053/j.ajkd.2013.08.032DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128105795URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Autoantibodies against a constituent of the glomerular basement membrane (GBM), the alpha 3-chain of type IV collagen, can cause both rapidly progressive glomerulonephritis and alveolar hemorrhage, referred to as anti-GBM disease or Goodpasture disease. Anti-GBM antibodies generally are of immunoglobulin G subclass 1 (IgG1) and can in most cases readily be detected in the circulation using enzyme-linked immunosorbent assays (ELISAs). We report 4 cases in which anti-GBM ELISA yielded negative or borderline results despite life-threatening disease. All 4 patients had positive results by IgG4 anti-GBM ELISA and all had undetectable anti-neutrophil cytoplasmic antibody. All cases were confirmed with kidney biopsy. Two of the patients showed higher signal in anti-GBM ELISA when using a nondenaturing coating buffer. All 4 were young women with severe alveolar hemorrhage and favorable renal outcome, suggesting that patients with predominance of IgG4 autoantibodies may constitute a distinct subgroup of anti-GBM disease. We conclude that patients with idiopathic alveolar hemorrhage can have anti-GBM disease detected by only IgG subclass-specific tests or kidney biopsy.
Ämnesord och genrebeteckningar
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Anti-glomerular basement membrane (anti-GBM); Goodpasture disease; immunoglobulin G4 (IgG4)
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Herlitz, HansSahlgrens University Hospital, Sweden
(författare)
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Lundberg, SigridKarolinska Institutet
(författare)
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Selga, DainaSkåne University Hospital, Sweden
(författare)
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Molne, JohanSahlgrens University Hospital, Sweden
(författare)
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Wieslander, JorgenEurodiagnost AB, Sweden
(författare)
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Segelmark, MårtenÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Njurmedicinska kliniken US(Swepub:liu)marse71
(författare)
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Skåne University Hospital, SwedenSahlgrens University Hospital, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Kidney Diseases: Elsevier63:2, s. 289-2930272-63861523-6838
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