Sökning: onr:"swepub:oai:DiVA.org:liu-104282" > Circulating Anti-Gl...
Fältnamn | Indikatorer | Metadata |
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000 | 03449naa a2200421 4500 | |
001 | oai:DiVA.org:liu-104282 | |
003 | SwePub | |
008 | 140214s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128105795 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1042822 URI |
024 | 7 | a https://doi.org/10.1053/j.ajkd.2013.08.0322 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1281057952 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ohlsson, Sophieu Skåne University Hospital, Sweden4 aut |
245 | 1 0 | a Circulating Anti-Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti-Glomerular Basement Membrane Disease |
264 | 1 | b Elsevier,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Autoantibodies against a constituent of the glomerular basement membrane (GBM), the alpha 3-chain of type IV collagen, can cause both rapidly progressive glomerulonephritis and alveolar hemorrhage, referred to as anti-GBM disease or Goodpasture disease. Anti-GBM antibodies generally are of immunoglobulin G subclass 1 (IgG1) and can in most cases readily be detected in the circulation using enzyme-linked immunosorbent assays (ELISAs). We report 4 cases in which anti-GBM ELISA yielded negative or borderline results despite life-threatening disease. All 4 patients had positive results by IgG4 anti-GBM ELISA and all had undetectable anti-neutrophil cytoplasmic antibody. All cases were confirmed with kidney biopsy. Two of the patients showed higher signal in anti-GBM ELISA when using a nondenaturing coating buffer. All 4 were young women with severe alveolar hemorrhage and favorable renal outcome, suggesting that patients with predominance of IgG4 autoantibodies may constitute a distinct subgroup of anti-GBM disease. We conclude that patients with idiopathic alveolar hemorrhage can have anti-GBM disease detected by only IgG subclass-specific tests or kidney biopsy. | |
653 | a Anti-glomerular basement membrane (anti-GBM); Goodpasture disease; immunoglobulin G4 (IgG4) | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Herlitz, Hansu Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Lundberg, Sigridu Karolinska Institutet4 aut |
700 | 1 | a Selga, Dainau Skåne University Hospital, Sweden4 aut |
700 | 1 | a Molne, Johanu Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Wieslander, Jorgenu Eurodiagnost AB, Sweden4 aut |
700 | 1 | a Segelmark, Mårtenu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Njurmedicinska kliniken US4 aut0 (Swepub:liu)marse71 |
710 | 2 | a Skåne University Hospital, Swedenb Sahlgrens University Hospital, Sweden4 org |
773 | 0 | t American Journal of Kidney Diseasesd : Elsevierg 63:2, s. 289-293q 63:2<289-293x 0272-6386x 1523-6838 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:697201/FULLTEXT01.pdfx primaryx Raw objecty fulltext:preprint |
856 | 4 | u http://liu.diva-portal.org/smash/get/diva2:697201/FULLTEXT01 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104282 |
856 | 4 8 | u https://doi.org/10.1053/j.ajkd.2013.08.032 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128105795 |
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