Preterm lambs given intravenous dopamine show increased dopamine in their cerebrospinal fluid

• AimDopamine is used as an inotropic medication in preterm infants. The preterm human blood brain barrier (BBB) is permeable to intravascular dopamine, and the impact of exogenous dopamine on the preterm brain remains unknown. The preterm lamb model may be suitable for studying the cerebral impact of dopamine therapy whether its BBB permeability is similar to preterm human infants. We aimed to examine BBB permeability to exogenous dopamine in the preterm lamb, by measuring dopamine levels in the cerebrospinal fluid (CSF). MethodsNine preterm foetal lambs (125-130days, term=147days) were given either dopamine at 10g/kg/min (dopamine, n=4) or saline (control, n=5). CSF, and plasma samples were taken for dopamine assay. ResultsThe median (range) baseline CSF dopamine level for the combined control and dopamine groups (n=9) was 0.10(0.03-0.16)ng/mL, and baseline plasma dopamine was 0.30(0.13-0.84) ng/mL. The dopamine lambs showed increase in CSF dopamine to 3.91(1.87-11.35)ng/mL with plasma dopamine increased to 14.2 (9.1-57.9)ng/mL. No change was found in the control lambs. ConclusionIn the preterm lamb, the BBB permeability and pharmacokinetics to dopamine infusion are similar to findings in the preterm human infant, supporting applicability of the preterm lamb model for studying effects of dopamine infusion in the preterm human brain.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Blood brain barrier; Dopamine; Hypotension; Infants; Preterm

MEDICINE

MEDICIN

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