Sökning: onr:"swepub:oai:DiVA.org:liu-106858" > Soluble Fas ligand ...
Fältnamn | Indikatorer | Metadata |
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000 | 05061naa a2200445 4500 | |
001 | oai:DiVA.org:liu-106858 | |
003 | SwePub | |
008 | 140523s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1068582 URI |
024 | 7 | a https://doi.org/10.1016/j.atherosclerosis.2014.01.0302 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Szymanowski, Aleksanderu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US4 aut0 (Swepub:liu)alesz45 |
245 | 1 0 | a Soluble Fas ligand is associated with natural killer cell dynamics in coronary artery disease |
264 | 1 | b Elsevier,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Objective: Apoptosis of natural killer (NK) cells is increased in patients with coronary artery disease (CAD) and may explain why NK cell levels are altered in these patients. Soluble forms of Fas and Fas ligand (L) are considered as markers of apoptosis. Here, we investigated whether plasma levels of Fas and FasL were associated with NK cell apoptosis and NK cell levels in CAD patients. Methods: Fas and FasL in plasma were determined by ELISA in 2 cohorts of CAD patients; one longitudinal study measuring circulating NK cells and apoptotic NK cells by flow cytometry 1 day, 3 months and 12 months after a coronary event and one cross-sectional study measuring NK cell apoptosis ex vivo. Both studies included matched healthy controls. Fas and FasL were also determined in supernatants from NK cells undergoing cytokine-induced apoptosis in cell culture. Results: In the 12-month longitudinal study, plasma FasL increased by 15% (p less than 0.001) and NK cell levels by 31% (p less than 0.05) while plasma Fas did not change. Plasma FasL and NK cell levels were significantly related at 3 months and 12 months, r = 0.40, p less than 0.01. Furthermore, plasma FasL, but not plasma Fas, correlated with NK cell apoptosis ex vivo in CAD patients, r = 0.54, p less than 0.05. In vitro, cytokine-induced apoptosis of NK cells resulted in abundant release of FasL. Conclusion: In CAD patients, FasL in plasma is associated with both apoptotic susceptibility of NK cells and dynamic changes in circulating NK cells. NK cells are also themselves a potential source of soluble FasL. Our findings link NK cell status to a soluble marker with possible atheroprotective effects thereby supporting a beneficial role of NK cells in CAD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a Acute coronary syndrome; Coronary artery disease; Immune system; Leukocytes; Natural killer cells; Apoptosis | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Li, Weiu Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet4 aut0 (Swepub:liu)weili19 |
700 | 1 | a Lundberg, Annau Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet4 aut0 (Swepub:liu)annli40 |
700 | 1 | a Evaldsson, Chamillyu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Klinisk kemi4 aut0 (Swepub:liu)chaga42 |
700 | 1 | a Nilsson, Lennartu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US4 aut0 (Swepub:liu)lenni29 |
700 | 1 | a Backteman, Karinu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)karba43 |
700 | 1 | a Ernerudh, Janu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15 |
700 | 1 | a Jonasson, Lenau Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US4 aut0 (Swepub:liu)lenjo59 |
710 | 2 | a Linköpings universitetb Avdelningen för kardiovaskulär medicin4 org |
773 | 0 | t Atherosclerosisd : Elsevierg 233:2, s. 616-622q 233:2<616-622x 0021-9150x 1879-1484 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:720108/FULLTEXT02.pdfx primaryx Raw objecty fulltext:preprint |
856 | 4 | u https://doi.org/10.1016/j.atherosclerosis.2014.01.030 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106858 |
856 | 4 8 | u https://doi.org/10.1016/j.atherosclerosis.2014.01.030 |
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