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Integrated genomic ...
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment
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- Gustafsson, Mika (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Edström, Måns (författare)
- Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Clinical and Experimental Medicine, Faculty of Health Sciences, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation, Linköping University, Linköping, Sweden
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- Gawel, Danuta (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Nestor, Colm (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Wang, Hui (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Zhang, Huan (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Barrenäs, Fredrik (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Tojo, James (författare)
- Department of Clinical Neurosciences, Karolinska Institutet and Centrum for Molecular Medicine, Stockholm, Sweden
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- Kockum, Ingrid (författare)
- Karolinska Institutet,Karolinska Institute, Sweden Centre Molecular Med, Sweden
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- Olsson, Tomas (författare)
- Karolinska Institutet,Karolinska Institute, Sweden Centre Molecular Med, Sweden
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- Serra-Musach, Jordi (författare)
- Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain
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- Bonifaci, Nuria (författare)
- Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain
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- Angel Pujana, Miguel (författare)
- Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain
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- Ernerudh, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin,Clinical and Experimental Medicine, Faculty of Health Sciences, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation, Linköping University, Linköping, Sweden
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- Benson, Mikael (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Allergicentrum US,Barn- och ungdomskliniken i Linköping,The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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(creator_code:org_t)
- BioMed Central, 2014
- 2014
- Engelska.
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Ingår i: Genome Medicine. - : BioMed Central. - 1756-994X. ; 6:17
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://genomemedici...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Translational research typically aims to identify and functionally validate individual, disease-specific genes. However, reaching this aim is complicated by the involvement of thousands of genes in common diseases, and that many of those genes are pleiotropic, that is, shared by several diseases. Methods: We integrated genomic meta-analyses with prospective clinical studies to systematically investigate the pathogenic, diagnostic and therapeutic roles of pleiotropic genes. In a novel approach, we first used pathway analysis of all published genome-wide association studies (GWAS) to find a cell type common to many diseases. Results: The analysis showed over-representation of the T helper cell differentiation pathway, which is expressed in T cells. This led us to focus on expression profiling of CD4(+) T cells from highly diverse inflammatory and malignant diseases. We found that pleiotropic genes were highly interconnected and formed a pleiotropic module, which was enriched for inflammatory, metabolic and proliferative pathways. The general relevance of this module was supported by highly significant enrichment of genetic variants identified by all GWAS and cancer studies, as well as known diagnostic and therapeutic targets. Prospective clinical studies of multiple sclerosis and allergy showed the importance of both pleiotropic and disease specific modules for clinical stratification. Conclusions: In summary, this translational genomics study identified a pleiotropic module, which has key pathogenic, diagnostic and therapeutic roles.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gustafsson, Mika
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Edström, Måns
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Gawel, Danuta
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Nestor, Colm
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Wang, Hui
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Zhang, Huan
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visa fler...
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Barrenäs, Fredri ...
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Tojo, James
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Kockum, Ingrid
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Olsson, Tomas
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Serra-Musach, Jo ...
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Bonifaci, Nuria
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Angel Pujana, Mi ...
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Ernerudh, Jan
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Benson, Mikael
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Genome Medicine
- Av lärosätet
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Linköpings universitet
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Örebro universitet
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Karolinska Institutet