Sökning: onr:"swepub:oai:DiVA.org:liu-107715" >
Microcirculation as...
Microcirculation assessment using an individualized model for diffuse reflectance spectroscopy and conventional laser Doppler flowmetry
-
- Strömberg, Tomas (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
-
- Karlsson, Hanna (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
-
- Fredriksson, Ingemar (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan,Perimed AB, Järfälla, Sweden
-
visa fler...
-
- Nyström, Fredrik H. (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Endokrinmedicinska kliniken,Avdelningen för kardiovaskulär medicin
-
- Larsson, Marcus (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
-
visa färre...
-
(creator_code:org_t)
- SPIE - International Society for Optical Engineering, 2014
- 2014
- Engelska.
-
Ingår i: Journal of Biomedical Optics. - : SPIE - International Society for Optical Engineering. - 1083-3668 .- 1560-2281. ; 19:5, s. 057002-
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Microvascular assessment would benefit from co-registration of blood flow and hemoglobin oxygenation dynamics during stimulus response tests. We used a fiber-optic probe for simultaneous recording of white light diffuse reflectance (DRS; 475-850 nm) and laser Doppler flowmetry (LDF; 780 nm) spectra at two source-detector distances (0.4 and 1.2 mm). An inverse Monte Carlo algorithm, based on a multiparameter three-layer adaptive skin model, was used for analyzing DRS data. LDF spectra were conventionally processed for perfusion. The system was evaluated on volar forearm recordings of 33 healthy subjects during a 5-min systolic occlusion protocol. The calibration scheme and the optimal adaptive skin model fitted DRS spectra at both distances within 10%. During occlusion, perfusion decreased within 5 s while oxygenation decreased slowly (mean time constant 61 s; dissociation of oxygen from hemoglobin). After occlusion release, perfusion and oxygenation increased within 3 s (inflow of oxygenized blood). The increased perfusion was due to increased blood tissue fraction and speed. The supranormal hemoglobin oxygenation indicates a blood flow in excess of metabolic demands. In conclusion, by integrating DRS and LDF in a fiber-optic probe, a powerful tool for assessment of blood flow and oxygenation in the same microvascular bed has been presented.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas