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The placenta in tox...
The placenta in toxicology. Part I : Animal models in toxicology
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- Buse, Eberhard (författare)
- Covance Laboratories, Münster, Germany
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- Häeger, Jan-Dirk (författare)
- Department of Anatomy, University of Veterinary Medicine, Hannover, Germany
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- Svensson-Arvelund, Judit, 1982- (författare)
- Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet
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- Markert, Udo R (författare)
- Placenta-Labor, Department of Obstetrics, University Hospital, Jena, Germany
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- Faas, Marijke M (författare)
- University Medical Centre Groningen, University of Groningen, The Netherlands
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- Ernerudh, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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- Dixon, Darlene (författare)
- NIEHS, NTP, Molecular Pathogenesis, Research Triangle Park, North Carolina, USA
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- Cline, J Mark (författare)
- Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
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- Pfarrer, Christiane (författare)
- Department of Anatomy, University of Veterinary Medicine, Hannover, Germany
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(creator_code:org_t)
- 2013-04-02
- 2014
- Engelska.
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Ingår i: Toxicologic pathology (Print). - : Sage Publications. - 0192-6233 .- 1533-1601. ; 42:2, s. 314-326
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The immune system represents a key defense mechanism against potential pathogens and adverse non-self materials. During pregnancy, the placenta is the point of contact between the maternal organism and non-self proteins of the fetal allograft and hence undoubtedly fulfils immune functions. In the placenta bacteria, foreign (non-self) proteins and proteins that might be introduced in toxicological studies or by medication are barred from reaching the progeny, and the maternal immune system is primed for acceptance of non-maternal fetal protein. Both immunologic protection of the fetus and acceptance of the fetus by the mother require effective mechanisms to prevent an immunologic fetomaternal conflict and to keep both organisms in balance. This is why the placenta requires toxicological consideration in view of its immune organ function. The following articles deal with placenta immune-, control-, and tolerance mechanisms in view of both fetal and maternal aspects. Furthermore, models for experimental access to placental immune function are addressed and the pathological evaluation is elucidated. "The Placenta as an Immune Organ and Its Relevance in Toxicological Studies" was subject of a continuing education course at the 2012 Society of Toxicologic Pathology meeting held in Boston, MA.
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