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Two insulin gene si...
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations
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- Laine, Antti-Pekka (författare)
- Immunogenetics Laboratory, University of Turku, Finland
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- Holmberg, Hanna (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Nilsson, Anita (författare)
- Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Sweden
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- Örtqvist, Eva (författare)
- Karolinska Institutet
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- Kiviniemi, Minna (författare)
- Immunogenetics Laboratory, University of Turku, Finland
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- Vaarala, Outi (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet,Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
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- Åkerblom, Hans K (författare)
- Hospital for Children and Adolescents, University of Helsinki, Finland
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- Simell, Olli (författare)
- Department of Paediatrics, University of Turku, Turku, Finland
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- Knip, Mikael (författare)
- Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland / Department of Pediatrics, Tampere University Hospital, Tampere, Finland
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- Ludvigsson, Johnny (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Ivarsson, Sten (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Larsson, Karin (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ilonen, Jorma (författare)
- Immunogenetics Laboratory, University of Turku, Finland / Department of Clinical Microbiology, University of Kuopio, Finland
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- Ramelius, Anita (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
- Hindawi Limited, 2007
- 2007
- Engelska.
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Ingår i: Disease Markers. - : Hindawi Limited. - 0278-0240 .- 1875-8630. ; 23:3, s. 139-45
- Relaterad länk:
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http://downloads.hin...
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http://iospress.meta...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time-resolved fluorometry reading. Distribution of the genotypes at both positions differed significantly among the affected children compared to the controls. The risk genotypes (CC, AA) were significantly more common in Finland than in Sweden, both among patients and controls. The VNTR genotype homozygous for the protective class III alleles showed a significantly stronger protective effect than the heterozygote (p=0.02). Analyzing both SNPs enabled the detection of VNTR class III subclasses IIIA and IIIB. The observed significance between effects of the protective genotypes was due to the strong protective effect of the IIIA/IIIA genotype. IIIA/IIIA was the only genotype with significant discrepancy between protective effects compared to the other class III genotypes. These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both -23HphI and -2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Type 1 diabetes
- insulin gene region
- Finnish population
- screening for genetic risk
- screening for
- Finnish population
- type 1 diabetes
- insulin gene region
- genetic risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Laine, Antti-Pek ...
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Holmberg, Hanna
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Nilsson, Anita
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Örtqvist, Eva
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Kiviniemi, Minna
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Vaarala, Outi
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visa fler...
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Åkerblom, Hans K
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Simell, Olli
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Knip, Mikael
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Ludvigsson, John ...
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Ivarsson, Sten
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Larsson, Karin
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Lernmark, Åke
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Ilonen, Jorma
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Ramelius, Anita
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Disease Markers
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet
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Lunds universitet