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Trend of clinical o...
Trend of clinical outcome and surrogate markers during titration of β-blocker in heart failure patients with reduced ejection fraction : relevance of achieved heart rate and β-blocker dose
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- Kato, Naoko (författare)
- University of Tokyo, Japan
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- Kinugawa, Koichiro (författare)
- University of Tokyo, Japan
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- Imamura, Teruhiko (författare)
- University of Tokyo, Japan
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- Muraoka, Hironori (författare)
- University of Tokyo, Japan
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- Minatsuki, Shun (författare)
- University of Tokyo, Japan
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- Inaba, Toshiro (författare)
- University of Tokyo, Japan
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- Maki, Hisataka (författare)
- University of Tokyo, Japan
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- Shiga, Taro (författare)
- University of Tokyo, Japan
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- Hatano, Masaru (författare)
- University of Tokyo, Japan
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- Yao, Atsushi (författare)
- University of Tokyo, Japan
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- Komuro, Issei (författare)
- University of Tokyo, Japan
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- Nagai, Ryozo (författare)
- University of Tokyo, Japan
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(creator_code:org_t)
- Japanese Circulation Society, 2013
- 2013
- Engelska.
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Ingår i: Circulation Journal. - : Japanese Circulation Society. - 1346-9843 .- 1347-4820. ; 77:4, s. 1001-1008
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND:The aim of this study was to examine trends of clinical outcome and to clarify surrogate markers when titrating β-blocker in heart failure patients with reduced left ventricular ejection fraction (HFrEF, LVEF <50%).METHODS AND RESULTS:Consecutive HFrEF patients starting on β-blocker were divided into 2 groups according to time of dose fixation attainment: before 31 December 2005 (group 1, n=108) or after 1 January 2006 (group 2, n=119). There were no significant differences in patient characteristics between the 2 groups at baseline. Beta-blocker fixed dose was higher with lower resting heart rate in group 2 (6.2±5.7mg/day vs. 9.5±9.1mg/day in carvedilol equivalent dose, P=0.001; 74.2±11.1beats/min vs. 70.2±9.7beats/min, P=0.004). The rate of HF hospitalization and/or all-cause death after 36 months was lower in group 2 than in group 1 (22% vs. 38%, P=0.011; hazard ratio, 0.90; P=0.012). Cox regression analysis showed that β-blocker ≥10mg/day and achieved heart rate ≤71beats/min predicted a better outcome (both P<0.05).CONCLUSIONS:Recent improvement of clinical outcome among HFrEF patients may be attributable to the up-titration policy accompanying lowered heart rate. Resting heart rate ≤71beats/min and β-blocker ≥10mg/day (ie, 50% of the target dose for Japanese patients) could be surrogate markers when titrating β-blocker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Beta-blocker; Heart failure; Heart rate; Morbidity; Mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kato, Naoko
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Kinugawa, Koichi ...
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Imamura, Teruhik ...
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Muraoka, Hironor ...
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Minatsuki, Shun
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Inaba, Toshiro
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visa fler...
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Maki, Hisataka
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Shiga, Taro
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Hatano, Masaru
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Yao, Atsushi
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Komuro, Issei
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Nagai, Ryozo
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visa färre...
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