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Successful conversi...
Successful conversion to everolimus after cytomegalovirus infection in a heart transplant recipient
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- Imamura, Teruhiko (författare)
- University of Tokyo, Japan
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- Shiga, Taro (författare)
- University of Tokyo, Japan
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- Kinugawa, Koichiro (författare)
- University of Tokyo, Japan
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- Kato, Naoko (författare)
- University of Tokyo, Japan
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- Endo, Miyoko (författare)
- Tokyo University Hospital, Japan
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- Inaba, Toshiro (författare)
- University of Tokyo, Japan
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- Maki, Hisataka (författare)
- University of Tokyo, Japan
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- Hatano, Masaru (författare)
- University of Tokyo, Japan
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- Yao, Atsushi (författare)
- University of Tokyo, Japan
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- Hirata, Yasunobu (författare)
- University of Tokyo, Japan
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- Nagai, Ryozo (författare)
- University of Tokyo, Japan
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(creator_code:org_t)
- International Heart Journal Association, 2012
- 2012
- Engelska.
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Ingår i: International Heart Journal. - : International Heart Journal Association. - 1349-2365 .- 1349-3299. ; 53:3, s. 199-201
- Relaterad länk:
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https://www.jstage.j...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CM V infection, but is often associated with neutropenia, especially when used with mycophenolate mophetil (MMF). We experienced an HTx recipient with positive CMV antigenemia who suffered progressive neutropenia after administration of VGC. We switched MMF to everolimus (EVL) and assay for CM V antigenemia was constantly negative even after discontinuation of VGC. In all other 14 HTx recipients who received EVL for any reason, we found that assay for CMV antigenemia remained negative throughout the period of EVL administration. Considering the prophylactic effect on CMV, EVL can not only be an alternative to rescue from comorbidity, but might also be indicated earlier especially in CMV-seronegative HTx recipients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Heart transplantation; Cytomegalovirus; Everolimus; Neutropenia; Valganciclovir
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Imamura, Teruhik ...
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Shiga, Taro
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Kinugawa, Koichi ...
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Kato, Naoko
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Endo, Miyoko
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Inaba, Toshiro
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visa fler...
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Maki, Hisataka
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Hatano, Masaru
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Yao, Atsushi
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Hirata, Yasunobu
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Nagai, Ryozo
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visa färre...
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