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Temporally-patterne...
Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury
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- Tabansky, Inna (författare)
- Rockefeller University, NY 10065 USA
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- Wells Quinkert, Amy (författare)
- Rockefeller University, NY 10065 USA
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- Rahman, Nadera (författare)
- Rockefeller University, NY 10065 USA
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- Zev Muller, Salomon (författare)
- Rockefeller University, NY 10065 USA
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- Lofgren, Jesper (författare)
- Linköpings universitet,Hälsouniversitetet,Rockefeller University, NY 10065 USA
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- Rudling, Johan (författare)
- Linköpings universitet,Hälsouniversitetet,Rockefeller University, NY 10065 USA
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- Goodman, Alyssa (författare)
- Rockefeller University, NY 10065 USA
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- Wang, Yingping (författare)
- Rockefeller University, NY 10065 USA
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- Pfaff, Donald W. (författare)
- Rockefeller University, NY 10065 USA
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Behavioural Brain Research. - : Elsevier. - 0166-4328 .- 1872-7549. ; 273, s. 123-132
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Deep brain stimulation; Traumatic brain injury; Generalized arousal; Mouse; Central thalamus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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