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Infections, antibio...
Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels
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- Hanberger, Håkan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Antonelli, Massimo (författare)
- Policlinico University of A. Gemelli, Rome, Italy
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- Holmbom, Martin (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Lipman, Jeffrey (författare)
- University of Queensland, Herston, Australia
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- Pickkers, Peter (författare)
- Radboud University Medical Centre, Nijmegen, The Netherlands
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- Leone, Marc (författare)
- Aix Marseille University, France
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- Rello, Jordi (författare)
- University Autonoma of Barcelona, Spain
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- Sakr, Yasser (författare)
- Friedrich-Schiller University, Jena, Germany
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- Walther, Sten (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland
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- Vanhems, Philippe (författare)
- University of Lyon 1, France
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- Vincent, Jean-Louis (författare)
- University Libre Bruxelles, Belgium
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(creator_code:org_t)
- 2014-09-22
- 2014
- Engelska.
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Ingår i: BMC Infectious Diseases. - : BioMed Central. - 1471-2334. ; 14:513
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://bmcinfectdis...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Antimicrobial resistance is an increasing concern in ICUs worldwide. Infection with an antibiotic resistant (ABR) strain of an organism is associated with greater mortality than infection with the non-resistant strain, but there are few data assessing whether being admitted to an intensive care unit (ICU) with high levels of antimicrobial resistance is associated with a worse outcome than being admitted to an ICU with low rates of resistance. The aim of this study was, therefore, to compare the characteristics of infections and antibiotic treatments and patient outcomes in patients admitted to ICUs in countries considered as having high levels of antibiotic resistance and those admitted to ICUs in countries considered as having low levels of antibiotic resistance. Methods: Data from the large, international EPIC II one-day point prevalence study on infections in patients hospitalized in ICUs were used. For the current study, we compared the data obtained from patients from two groups of countries: countries with reported MRSA rates of greater than= 25% (highABR: Greece, Israel, Italy, Malta, Portugal, Spain, and Turkey) and countries with MRSA rates of less than 5% (lowABR: Denmark, Finland, Netherlands, Norway, and Sweden). Results: On the study day, 1187/2204 (53.9%) patients in the HighABR ICUs were infected and 255/558 (45.7%) in the LowABR ICUs (P less than 0.01). Patients in the HighABR ICUs were more severely ill than those in the LowABR ICUs, as reflected by a higher SAPS II score (35.6 vs 32.7, P less than 0.05) and had longer median ICU (12 days vs 5 days) and hospital (24 days vs 16 days) lengths of stay. They also had higher crude ICU (20.0% vs 15.4%) and hospital (27.0% vs 21.5%) mortality rates (both P less than 0.05). However, after multivariable adjustment and matched pair analysis there were no differences in ICU or hospital mortality rates between High or LowABR ICU patients overall or among those with infections. Conclusions: Being hospitalized in an ICU in a region with high levels of antimicrobial resistance is not associated per se with a worse outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Infection; Critically ill; Antibiotic; Resistance
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hanberger, Håkan
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Antonelli, Massi ...
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Holmbom, Martin
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Lipman, Jeffrey
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Pickkers, Peter
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Leone, Marc
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visa fler...
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Rello, Jordi
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Sakr, Yasser
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Walther, Sten
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Vanhems, Philipp ...
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Vincent, Jean-Lo ...
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visa färre...
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