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Etiology of Childho...
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Becker-Dreps, SylviaUniversity of N Carolina, NC 27599 USA
(författare)
Etiology of Childhood Diarrhea After Rotavirus Vaccine Introduction A Prospective, Population-based Study in Nicaragua
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Lippincott, Williams andamp; Wilkins,2014
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-112630
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-112630URI
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https://doi.org/10.1097/INF.0000000000000427DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Merck Investigator-Initiated Studies Program; Thrasher Research Fund; Fogarty International Center at the National Institutes of Health [5K01TW008401-04]; NETROPICA [05-N-2010]
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Background: Nicaragua was the first developing nation to implement routine immunization with the pentavalent rotavirus vaccine (RV5). In this RV5-immunized population, understanding infectious etiologies of childhood diarrhea is necessary to direct diarrhea treatment and prevention efforts. Methods: We followed a population-based sample of children less than5 years in Leon, Nicaragua for diarrhea episodes through household visits. Information was obtained on RV5 history and sociodemographics. Stool samples collected during diarrhea episodes and among healthy children underwent laboratory analysis for viral, bacterial and parasitic enteropathogens. Detection frequency and incidence of each enteropathogen was calculated. Results: The 826 children in the cohort experienced 677 diarrhea episodes during 607.5 child-years of exposure time (1.1 episodes per child-year). At least 1 enteropathogen was detected among 61.1% of the 337 diarrheal stools collected. The most common enteropathogens among diarrheal stools were: norovirus (20.4%), sapovirus (16.6%), enteropathogenic Escherichia coli (11.3%), Entamoeba histolytica/dispar (8.3%), Giardia lamblia (8.0%) and enterotoxigenic E. coli (7.7%), with rotavirus detected among 5.3% of diarrheal stools. Enteropathogenic Escherichia coli and enterotoxigenic E. coli were frequently detected among stools from healthy children. Among children with diarrhea, norovirus was more commonly detected among younger children (less than2 years) and G. lamblia was more commonly detected among older children (2-4 years). The mean age of rotavirus detection was 34.6 months. Conclusions: In this Central American community after RV5 introduction, rotavirus was not commonly detected among children with diarrhea. Prevention and appropriate management of norovirus and sapovirus should be considered to further reduce the burden of diarrheal disease.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bucardo, FilemonNational Autonomous University of Nicaragua, Nicaragua
(författare)
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Vilchez, SamuelNational Autonomous University of Nicaragua, Nicaragua
(författare)
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Enrique Zambrana, LuisCentre Epidemiol and Health CIDS, Nicaragua
(författare)
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Liu, LanUniversity of N Carolina, NC USA
(författare)
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Weber, David J.University of N Carolina, NC 27599 USA
(författare)
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Pena, RodolfoCentre Health Research CIS, Nicaragua
(författare)
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Barclay, LeslieCentre Disease Control and Prevent, GA USA
(författare)
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Vinje, JanCentre Disease Control and Prevent, GA USA
(författare)
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Hudgens, Michael G.University of N Carolina, NC USA
(författare)
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Nordgren, JohanLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)johno12
(författare)
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Svensson, LennartLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet(Swepub:liu)lensv66
(författare)
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Morgan, Douglas R.University of N Carolina, NC 27599 USA; Vanderbilt University, TN 37235 USA
(författare)
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Espinoza, FelixNational Autonomous University of Nicaragua, Nicaragua
(författare)
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Paniagua, MargaritaNational Autonomous University of Nicaragua, Nicaragua
(författare)
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University of N Carolina, NC 27599 USANational Autonomous University of Nicaragua, Nicaragua
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Pediatric Infectious Disease Journal: Lippincott, Williams andamp; Wilkins33:11, s. 1156-11630891-36681532-0987
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Bucardo, Filemon
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Vilchez, Samuel
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Liu, Lan
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Weber, David J.
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Pena, Rodolfo
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Barclay, Leslie
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Vinje, Jan
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Hudgens, Michael ...
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Morgan, Douglas ...
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Espinoza, Felix
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