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  • Duits, Flora H.Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands,University of Paris 06, France; University of Paris 06, France (author)

The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean?

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-04-09
  • Elsevier,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-113059
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113059URI
  • https://doi.org/10.1016/j.jalz.2013.12.023DOI
  • https://lup.lub.lu.se/record/4430352URI
  • https://gup.ub.gu.se/publication/202066URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:130182931URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Alzheimer Nederland fund; Stichting VUMC fund; Stichting Dioraphte
  • Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-beta(1-42) (A beta(42)), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimers disease (AD). Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/A beta(42) ratio and 0.08 for the p-tau/A beta(42) ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/A beta(42) ratio. Conclusions: A tau/A beta(42) ratio of greater than0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Teunissen, Charlotte E.Vrije University of Amsterdam, Netherlands (author)
  • Bouwman, Femke H.Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands (author)
  • Visser, Pieter-JelleVrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands; University of Maastricht, Netherlands (author)
  • Mattsson, Niklas,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre Imaging Neurodegenerat Disease, CA USA(Swepub:gu)xmattn (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,UCL Institute Neurol, England(Swepub:gu)xzethe (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Sweden(Swepub:gu)xbleka (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Sweden(Swepub:lu)mphy-ohn (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Sweden(Swepub:lu)psyk-lmi (author)
  • Andreasen, NielsKarolinska Institutet,Karolinska University Hospital, Sweden (author)
  • Marcusson, JanÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Geriatriska kliniken,Vrije University of Amsterdam, Netherlands(Swepub:liu)janma25 (author)
  • Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Sweden(Swepub:gu)xwaand (author)
  • Olde Rikkert, MarcelDonders Institute Brain Cognit and Behav, Netherlands (author)
  • Tsolaki, MagdaAristotle University of Thessaloniki, Greece (author)
  • Parnetti, LucillaUniversity of Perugia, Italy (author)
  • Herukka, Sanna-KaisaUniversity of Eastern Finland, Finland; Kuopio University Hospital, Finland (author)
  • Hampel, HaraldUniversity of Paris 06, France; University of Paris 06, France (author)
  • De Leon, Mony J.NYU, NY USA (author)
  • Schroeder, JohannesHeidelberg University, Germany (author)
  • Aarsland, DagKarolinska Institutet,Stavanger University Hospital, Norway (author)
  • Blankenstein, Marinus A.Vrije University of Amsterdam, Netherlands (author)
  • Scheltens, PhilipVrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands (author)
  • van der Flier, Wiesje M.Vrije University of Amsterdam, Netherlands (author)
  • Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, NetherlandsUniversity of Paris 06, France; University of Paris 06, France (creator_code:org_t)

Related titles

  • In:Alzheimer's & Dementia: Elsevier10:6, s. 713-7231552-52601552-5279

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