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Peripheral nerve as...
Peripheral nerve as an osmometer : role of the perineurium in frog sciatic nerve.
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- Ask, Per (författare)
- Linköpings universitet,Fysiologisk mätteknik,Tekniska högskolan
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Levitan, H (författare)
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Robinson, P J (författare)
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visa fler...
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Rapoport, S I (författare)
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visa färre...
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(creator_code:org_t)
- 1983
- 1983
- Engelska.
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Ingår i: American Journal of Physiology. - 0002-9513 .- 2163-5773. ; 244:1, s. C75-81
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Measurements of volume and hydrostatic pressure in the frog sciatic nerve in vitro demonstrate that the nerve acts as an osmometer, in large part because the perineurium is a semipermeable membrane for water flow. Endoneurial hydrostatic pressure in nerves in isotonic Ringer exceeds bath pressure by about 7 mmHg. In Ringer made hypertonic by addition of sucrose, nerve volume and endoneurial pressure fall linearly in relation to 1/osmolality. The slope of the plot of pressure against volume provides a value for nerve compliance equal to 0.006 mm2/mmHg. Calculations based on the model of the nerve as an osmometer indicate that the nerve has an osmotically "inactive" volume equal to 0.19 mm3/mm, which is about 75% of the total volume of a nerve segment of unit length in normal Ringer. Perineurial hydraulic conductivity (Lp) equals 7.5 x 10(-13) cm3.s-1.dyn-1, a value characteristic of nonleaky epithelia. The perineurium is an elastic tissue with a constant modulus of elasticity equal to 3 x 10(6) dyn/cm2 when not markedly stretched and may limit nerve swelling under pathological conditions of nerve edema.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Samhällsbyggnadsteknik -- Geoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Civil Engineering -- Geotechnical Engineering (hsv//eng)
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- art (ämneskategori)
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