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A potential-gated molecularly imprinted smart electrode for nicotinamide analysis
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- Karimian, Najmeh (författare)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska högskolan,Ferdowsi University of Mashhad, Iran
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- Hossein Arbab Zavar, Mohammad (författare)
- Ferdowsi University of Mashhad, Iran
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- Chamsaz, Mahmoud (författare)
- Ferdowsi University of Mashhad, Iran
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- Ashraf, Narges (författare)
- Ferdowsi University of Mashhad, Iran
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- Turner, Anthony (författare)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska högskolan
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- Tiwari, Ashutosh (författare)
- Linköpings universitet,Biosensorer och bioelektronik,Tekniska högskolan,Tekidag AB, UCS, Linköping, Sweden
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(creator_code:org_t)
- 2015
- Engelska.
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 5:44, s. 35089-35096
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Triggered surface responsiveness paves the way for smart sensor technologies that not only have tunable retention, but also provide sensing through a built-in programming of electrode material. In this study, we report a potential-gated electrochemical sensor for determination of nicotinamide (NAM) based on a molecularly imprinted overoxidised polypyrrole electrode. The sensitive layer was prepared by electropolymerisation of pyrrole on a glassy carbon electrode in the presence of NAM as a template molecule, followed by alkali extraction. Electrochemical methods were used to monitor the processes of electropolymerisation, template removal and binding in the presence of a [Fe(CN)(6)](3-)/[Fe(CN)(6)](4-) redox couple as an electrochemical probe. Several factors affecting the performance of the MIP-modified electrode were investigated and optimized. The peak current of the ferro/ferricyanide couple decreased linearly with successive addition of NAM in the concentration range 0.9 x 10(-6) to 9.9 x 10(-3) M with a detection limit of 1.7 x 10(-7) M (S/N = 3). The molecularly-imprinted polymer (MIP) electrode had excellent recognition capability for NAM compared to structurally related molecules. Moreover, the reproducibility and repeatability of the NAM-imprinted electrode were all found to be satisfactory. The results from sample analysis confirmed the applicability of the NAM-imprinted electrode to reusable quantitative analysis in commercial pharmaceutical samples.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)