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VEGF-B promotes can...
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
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- Yang, Xiaojuan (författare)
- Karolinska Institute, Sweden; Tongji University, Peoples R China
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- Zhang, Yin (författare)
- Karolinska Institutet
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- Hosaka, Kayoko (författare)
- Karolinska Institutet
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- Andersson, Patrik (författare)
- Karolinska Institutet
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- Wang, Jian (författare)
- Karolinska Institute, Sweden
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- Tholander, Fredrik (författare)
- Karolinska Institutet
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- Cao, Ziquan (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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- Morikawa, Hiromasa (författare)
- Karolinska Institutet
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- Tegner, Jesper (författare)
- Karolinska Institutet
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- Yang, Yunlong (författare)
- Karolinska Institutet
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- Iwamoto, Hideki (författare)
- Karolinska Institute, Sweden
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- Lim, Sharon (författare)
- Karolinska Institutet
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- Cao, Yihai (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Karolinska Institute, Sweden; University of Leicester, England; Glenfield Hospital, England
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(creator_code:org_t)
- 2015-05-19
- 2015
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 112:22, s. E2900-E2909
- Relaterad länk:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The biological functions of VEGF-B in cancer progression remain poorly understood. Here, we report that VEGF-B promotes cancer metastasis through the remodeling of tumor microvasculature. Knockdown of VEGF-B in tumors resulted in increased perivascular cell coverage and impaired pulmonary metastasis of human melanomas. In contrast, the gain of VEGF-B function in tumors led to pseudonormalized tumor vasculatures that were highly leaky and poorly perfused. Tumors expressing high levels of VEGF-B were more metastatic, although primary tumor growth was largely impaired. Similarly, VEGF-B in a VEGF-A-null tumor resulted in attenuated primary tumor growth but substantial pulmonary metastases. VEGF-B also led to highly metastatic phenotypes in Vegfr1 tk(-/-) mice and mice treated with anti-VEGF-A. These data indicate that VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism. High expression levels of VEGF-B in two large-cohort studies of human patients with lung squamous cell carcinoma and melanoma correlated with poor survival. Taken together, our findings demonstrate that VEGF-B is a vascular remodeling factor promoting cancer metastasis and that targeting VEGF-B may be an important therapeutic approach for cancer metastasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- VEGF-B; metastasis; VEGFR1; VEGF-A; angiogenesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yang, Xiaojuan
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Zhang, Yin
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Hosaka, Kayoko
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Andersson, Patri ...
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Wang, Jian
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Tholander, Fredr ...
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visa fler...
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Cao, Ziquan
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Morikawa, Hiroma ...
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Tegner, Jesper
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Yang, Yunlong
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Iwamoto, Hideki
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Lim, Sharon
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Cao, Yihai
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Proceedings of t ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet