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Assessing the carci...
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis
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- Hu, Zhiwei (författare)
- Ohio State University, OH 43210 USA; Ohio State University, OH 43210 USA
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- Brooks, Samira A. (författare)
- University of N Carolina, NC 27599 USA
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- Dormoy, Valerian (författare)
- University of Strasbourg, France; University of Calif Irvine, CA 92697 USA
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- Hsu, Chia-Wen (författare)
- NIH, MD 20892 USA
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- Hsu, Hsue-Yin (författare)
- Tzu Chi University, Taiwan
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- Lin, Liang-Tzung (författare)
- Taipei Medical University, Taiwan
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- Massfelder, Thierry (författare)
- University of Strasbourg, France
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- Rathmell, W. Kimryn (författare)
- University of N Carolina, NC 27599 USA
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- Xia, Menghang (författare)
- NIH, MD 20892 USA
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- Al-Mulla, Fahd (författare)
- Tzu Chi University, Taiwan
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- Al-Temaimi, Rabeah (författare)
- Kuwait University, Kuwait
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- Amedei, Amedeo (författare)
- University of Firenze, Italy
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- Brown, Dustin G. (författare)
- Colorado State University, CO 80523 USA
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- Prudhomme, Kalan R. (författare)
- Oregon State University, OR 97331 USA
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- Colacci, Annamaria (författare)
- Environm Protect and Health Prevent Agency, Italy
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- Hamid, Roslida A. (författare)
- University of Putra Malaysia, Malaysia
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- Mondello, Chiara (författare)
- CNR, Italy
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- Raju, Jayadev (författare)
- Health Canada, Canada
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- Ryan, Elizabeth P. (författare)
- Colorado State University, CO 80523 USA
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- Woodrick, Jordan (författare)
- Georgetown University, DC 20057 USA
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- Scovassi, A. Ivana (författare)
- CNR, Italy
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- Singh, Neetu (författare)
- King Georges Medical University, India
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- Vaccari, Monica (författare)
- Environm Protect and Health Prevent Agency, Italy
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- Roy, Rabindra (författare)
- Georgetown University, DC 20057 USA
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- Forte, Stefano (författare)
- Mediterranean Institute Oncol, Italy
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- Memeo, Lorenzo (författare)
- Mediterranean Institute Oncol, Italy
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- Salem, Hosni K. (författare)
- Cairo University, Egypt
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- Lowe, Leroy (författare)
- Getting Know Canc, Canada
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- Jensen, Lasse (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
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- Bisson, William H. (författare)
- Oregon State University, OR 97331 USA
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- Kleinstreuer, Nicole (författare)
- Integrated Lab Syst Inc, NC 27709 USA
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(creator_code:org_t)
- 2015-06-22
- 2015
- Engelska.
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP): Policy B - Oxford Open Option B. - 0143-3334 .- 1460-2180. ; 36, s. S184-S202
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Angiogenesis is an important hallmark of cancer. We reviewed the various pathways controlling angiogenesis, summarized the possible role of specific environmental chemicals disrupting these pathways and listed assays for assessing the effects of low-dose exposures to chemicals in promoting tumor angiogenesis.One of the important hallmarks of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer cells, cancer stem cells and other cell types in the tumor stroma can disrupt the balance so that the tumor microenvironment favors tumor angiogenesis. These factors include vascular endothelial growth factor, endothelial tissue factor and other membrane bound receptors that mediate multiple intracellular signaling pathways that contribute to tumor angiogenesis. Though environmental exposures to certain chemicals have been found to initiate and promote tumor development, the role of these exposures (particularly to low doses of multiple substances), is largely unknown in relation to tumor angiogenesis. This review summarizes the evidence of the role of environmental chemical bioactivity and exposure in tumor angiogenesis and carcinogenesis. We identify a number of ubiquitous (prototypical) chemicals with disruptive potential that may warrant further investigation given their selectivity for high-throughput screening assay targets associated with proangiogenic pathways. We also consider the cross-hallmark relationships of a number of important angiogenic pathway targets with other cancer hallmarks and we make recommendations for future research. Understanding of the role of low-dose exposure of chemicals with disruptive potential could help us refine our approach to cancer risk assessment, and may ultimately aid in preventing cancer by reducing or eliminating exposures to synergistic mixtures of chemicals with carcinogenic potential.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Hu, Zhiwei
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Brooks, Samira A ...
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Dormoy, Valerian
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Hsu, Chia-Wen
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Hsu, Hsue-Yin
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Lin, Liang-Tzung
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visa fler...
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Massfelder, Thie ...
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Rathmell, W. Kim ...
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Xia, Menghang
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Al-Mulla, Fahd
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Al-Temaimi, Rabe ...
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Amedei, Amedeo
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Brown, Dustin G.
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Prudhomme, Kalan ...
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Colacci, Annamar ...
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Hamid, Roslida A ...
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Mondello, Chiara
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Raju, Jayadev
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Ryan, Elizabeth ...
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Woodrick, Jordan
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Scovassi, A. Iva ...
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Singh, Neetu
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Vaccari, Monica
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Roy, Rabindra
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Forte, Stefano
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Memeo, Lorenzo
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Salem, Hosni K.
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Lowe, Leroy
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Jensen, Lasse
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Bisson, William ...
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Kleinstreuer, Ni ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Carcinogenesis
- Av lärosätet
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Linköpings universitet