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Naringenin improves...
Naringenin improves learning and memory in an Alzheimer's disease rat model : Insights into the underlying mechanisms
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- Ghofrani, Saeed (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Cellular and Molecular Research Center and Department of Neuroscience, School of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran
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- Joghataei, Mohammad-Taghi (författare)
- Cellular and Molecular Research Center and Department of Neuroscience, School of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran
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- Mohseni, Simin (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Baluchnejadmojarad, Tourandokht (författare)
- Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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- Bagheri, Maryam (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
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- Khamse, Safoura (författare)
- Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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- Roghani, Mehrdad (författare)
- Neurophysiology Research Center, Shahed University, Tehran, Iran
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: European Journal of Pharmacology. - : Elsevier BV. - 0014-2999 .- 1879-0712. ; 764, s. 195-201
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulvestrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Naringenin
- Alzheimer’s disease
- Beta-Amyloid
- Learning and Memory
- Oxidative stress
- Apoptosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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